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1.发明申请
公开(公告)号：WO2021164905A1
公开(公告)日：2021-08-26
申请号：PCT/EP2020/080553
申请日：2020-10-30
Inventor： WOLFGANG, Matthias , KHINAST, Johannes , STRANZINGER, Sandra
Abstract: A method of determining information indicative of a material attribute of a composition, wherein the method comprises manufacturing the composition using a thermal manufacturing process, detecting detection data from the composition by low coherence interferometry during the manufacturing, in particular during said thermal manufacturing process, and determining the information based on the detected detection data.
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公开(公告)号：WO2019002319A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/067160
申请日：2018-06-26
Inventor： KHINAST, Johannes , KLEIN, Thomas , BRESCIANI, Massimo , FAULHAMMER, Eva , STRANZINGER, Sandra , MARKL, Daniel , ZEITLER, Jochen Axel
IPC: G01N21/3563 , G01N21/3581 , G01N21/59 , G01N21/85
Abstract: A device and a method for providing granular matter is described, wherein the device comprises a receiving container (101) configured and adjusted for receiving the granular matter (103), wherein the receiving container (101) has an output (104) for providing the granular matter (103) to a further processing and the device comprises a measuring unit (102) configured for measuring a density of the granular matter (103) in the receiving container (101) using terahertz spectroscopy.
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3.发明申请APPARATUS, METHOD AND SYSTEM FOR MOULDING A THERMOPLASTIC MATERIAL BY VACUUM COMPRESSION MOULDING 审中-公开用于通过真空压缩成型模制热塑性材料的装置，方法和系统
公开(公告)号：WO2015197830A1
公开(公告)日：2015-12-30
申请号：PCT/EP2015/064547
申请日：2015-06-26
Inventor： TREFFER, Daniel , GRUBBAUER, Johann , KOSCHER, Gerold , KLEIN, Thomas , KHINAST, Johannes
IPC: B29C33/68 , B29C43/14 , B29C43/56 , B29K105/00
CPC classification number: B29C43/14 , B29C33/68 , B29C43/027 , B29C43/361 , B29C43/52 , B29C43/56 , B29C43/58 , B29C2043/029 , B29C2043/3233 , B29C2043/3615 , B29C2043/563 , B29C2043/5816 , B29K2101/12 , B29K2105/0035 , B29L2031/40 , B29L2031/753
Abstract: There is provided an apparatus for molding a thermoplastic material into a homogenous sample body having a predetermined shape, the apparatus comprising: (a) a main body (110) comprising a first opening (112), a second opening and a hollow bore (116) connecting the first opening (112) with the second opening, the hollow bore (116) being adapted to receive a separation foil shaped to cover at least a part of the hollow bore surface; (b) a piston (120) adapted to fit moveably into the hollow bore (116) containing the separation foil; (c) a base plate (130) comprising a protrusion, wherein the base plate (130) is adapted to be inserted into the first opening (112) in such a manner that the protrusion extends into a part of the hollow bore (116) containing the separation foil, and wherein the base plate (130) is adapted to transfer heat from a heating unit to a thermoplastic material (150) resting on the protrusion (132); (d) a vacuum connector (142) adapted to be connected to a vacuum source; (e) a lid (140) adapted to fit moveably into the second opening and adapted to apply a force to the piston (120) when the vacuum connector (142) is connected to the vacuum source such that the piston (120) applies a compressing force to the thermoplastic material (150) resting on the protrusion. There are further provided a method and a system for molding a thermoplastic material into a homogenous sample body having a predetermined shape.
Abstract translation: 提供了一种用于将热塑性材料模制成具有预定形状的均匀样品体的装置，该装置包括：（a）主体（110），包括第一开口（112），第二开口和中空孔 ）将所述第一开口（112）与所述第二开口连接，所述中空孔（116）适于容纳形成为覆盖所述中空孔表面的至少一部分的分离箔; （b）适于可移动地装配到容纳分离箔的中空孔（116）中的活塞（120）; （c）包括突起的基板（130），其中所述基板（130）适于以突出部延伸到所述中空孔（116）的一部分中的方式插入所述第一开口（112） ，其中所述基板（130）适于将热量从加热单元传递到搁置在所述突起（132）上的热塑性材料（150）; （d）适于连接到真空源的真空连接器（142）; （e）适于可动地装配到所述第二开口中并且当所述真空连接器（142）连接到所述真空源时将力施加到所述活塞（120）的盖（140），使得所述活塞（120）施加 压缩到搁置在突起上的热塑性材料（150）的力。 还提供了一种用于将热塑性材料模制成具有预定形状的均匀样品体的方法和系统。
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4.发明申请
公开(公告)号：WO2021164904A1
公开(公告)日：2021-08-26
申请号：PCT/EP2020/080552
申请日：2020-10-30
Inventor： WOLFGANG, Matthias , WEISSENSTEINER, Michael , PÖLLITSCH, Simon , KHINAST, Johannes
Abstract: A method of determining information indicative of a material attribute of a pharmaceutical composition (100), wherein the method comprises detecting detection data from the composition (100) by low coherence interferometry, and determining the information indicative of the material attribute based on the detection data and using machine learning.
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公开(公告)号：WO2021204889A1
公开(公告)日：2021-10-14
申请号：PCT/EP2021/059085
申请日：2021-04-07
Applicant: RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , KARL-FRANZENS-UNIVERSITÄT GRAZ , TECHNISCHE UNIVERSITÄT GRAZ
Inventor： EDER, Simone , KOUTSAMANIS, Ioannis , KLEIN, Thomas , ROBLEGG, Eva , KHINAST, Johannes
Abstract: Beschrieben wird ein Verfahren zum Herstellen eines Wirkstoffträgers, wobei das Verfahren aufweist: i) Bereitstellen eines Polymers (112) an eine Heißschmelzextrusion (150), iii) Bereitstellen eines Treibmittels (113) an das Polymer (112), und iii) Extrudieren des Polymers (112) mittels der Heißschmelzextrusion (150) derart, dass das Treibmittel (113) mittels einer Reaktion Wirkstofftransport-geeignete Poren (121) in dem Polymer (112) erzeugt, um den Wirkstoffträger (120) bereitzustellen. Hierbei sind die Wirkstofftransport-geeigneten Poren (121) eingerichtet sind zum Aufnehmen eines Wirkstoffs (111) und/oder Freigeben des Wirkstoffs (111).
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Patent Agency Ranking6.发明申请A SYSTEM AND A METHOD FOR CONSTANT MICRO DOSING AND FEEDING OF POWDER MATERIAL 审中-公开一种用于粉末材料的恒定微计量和给料的系统和方法
公开(公告)号：WO2018065616A1
公开(公告)日：2018-04-12
申请号：PCT/EP2017/075578
申请日：2017-10-06
Inventor： KHINAST, Johannes , SLAMA, Eyke , FATHOLLAHI, Sara , KLEIN, Thomas , BESENHARD, Maximilian
Abstract: A system and a method for a constant micro dosing of powder material, comprising a control device,a cylinder comprising a first opening and a piston movably arranged inside the cylinder and controllable by the control device, wherein the piston is movable in the direction to or away from the first opening along a piston stroke direction. The cylinder is configured for storing the powder material between the piston and the first opening. The piston is configured for pushing the powder material through the first opening by moving along the piston stroke direction. Further the system and the method comprise a removing device for removing the powder material which is pushed out of the first opening of the cylinder. The control device is configured for controlling the piston and the removing device in a synchronized manner such that a predetermined amount of powder material pushed through the first opening is removable by the removing device.
Abstract translation: 一种用于粉末材料的恒定微量配量的系统和方法，包括控制装置，包括第一开口和活塞可移动地布置在所述汽缸内并且可由所述控制装置控制的活塞的汽缸，其中， 活塞可沿着活塞行程方向朝向或远离第一开口的方向移动。 气缸构造成用于将粉末材料储存在活塞与第一开口之间。 活塞构造成用于通过沿着活塞行程方向移动来推动粉末材料通过第一开口。 此外，该系统和方法包括用于移除从气缸的第一开口推出的粉末材料的移除装置。 控制装置构造成用于以同步方式控制活塞和移除装置，使得通过移除装置移除通过第一开口推动的预定量的粉末材料。
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7.发明申请MONITORING DISSOLUTION OF A DOSAGE FORM IN PROGRESS DURING DISSOLUTION BY LOW COHERENCE INTERFEROMETRY 审中-公开低相干干涉技术监测溶出溶出过程中溶出的剂量形式
公开(公告)号：WO2017162682A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/056718
申请日：2017-03-21
Inventor： BRESCIANI, Massimo , MARKL, Daniel , MERCURI, Annalisa , KHINAST, Johannes , KLEIN, Thomas
Abstract: A method of monitoring a property of a dissolution of an at least partially solid dosage form (103) during a dissolution process, the method comprising at least partially dissolving the dosage form (103), and during the dissolution of the dosage form (103), simultaneously monitoring the property of the dissolution of the dosage form (103) in progress by using a monitoring apparatus (101) based on low coherence interferometry.
Abstract translation: 监测溶解过程期间至少部分固体剂型（103）溶解特性的方法，所述方法包括至少部分溶解剂型（103），并且在 通过使用基于低相干干涉测量法的监测装置（101）同时监测剂型（103）的溶解，同时监测正在进行的剂型（103）的溶解性质。
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8.发明申请
公开(公告)号：WO2015022408A1
公开(公告)日：2015-02-19
申请号：PCT/EP2014/067449
申请日：2014-08-14
Inventor： TREFFER, Daniel , KHINAST, Johannes , GRUBBAUER, Johann , EITZLMAYR, Andreas , KOSCHER, Gerold , KLEIN, Thomas
CPC classification number: B29B9/06 , B29B9/065 , B29C47/0011 , B29C47/0014 , B29C47/0066 , B29C47/0893 , B29C47/30 , B29C47/402 , B29C47/822 , B29C47/862 , B29C47/864 , B29C2793/0027 , B29C2793/009 , B29C2947/92704 , B29C2947/92904 , B29K2995/0013 , B29K2995/0015 , Y02P70/263
Abstract: An apparatus (100) for manufacturing particles, wherein the apparatus (100) comprises a supply unit (102) adapted for supplying a viscous raw material, a perforated body (104) having a plurality of perforations (106) and arranged to receive the viscous raw material from the supply unit (102) to flow through the plurality of perforations (106), and a cutter (108) arranged so that the viscous raw material flowing out of the plurality of perforations (106) is cut into the particles by the cutter (108), wherein the apparatus (100) is configured so that, during manufacturing the particles, a temperature of at least a portion of the perforated body (104) is lower than a temperature of the viscous raw material flowing through the plurality of perforations (106), wherein the perforated body (104) and the cutter (108) are arranged relative to one another such that the cutter (108) is cooled by thermal exchange with the perforated body (104) during operation of the apparatus (100).
Abstract translation: 一种用于制造颗粒的设备（100），其中所述设备（100）包括适于供应粘性原料的供应单元（102），具有多个穿孔（106）的多孔体（104），并布置成接收粘性 来自供应单元（102）的原料流过多个穿孔（106），以及切割器（108），其布置成使得从多个穿孔（106）流出的粘性原料通过 切割器（108），其中所述设备（100）被构造成使得在制造所述颗粒期间，所述穿孔体（104）的至少一部分的温度低于流过所述多个 穿孔（106），其中穿孔体（104）和切割器（108）相对于彼此布置，使得在设备（100）的操作期间刀具（108）通过与多孔体（104）的热交换而被冷却 ）。
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9.发明申请A DEVICE AND A METHOD FOR PREPARING A FILLED PHARMACEUTICAL CAPSULE ON DEMAND WITH A PREDETERMINED AMOUNT OF AN ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开一种装置和一种用预定量的活性药物成分制备填充的药用胶囊的方法
公开(公告)号：WO2013164127A1
公开(公告)日：2013-11-07
申请号：PCT/EP2013/055846
申请日：2013-03-20
Inventor： KLEIN, Thomas , KHINAST, Johannes
CPC classification number: A61J3/074 , A61J7/0445 , A61J2200/74 , A61J2205/70
Abstract: A device for preparing a filled pharmaceutical capsule on demand with a predetermined amount of an active pharmaceutical ingredient is described. The device comprises a container accommodation unit adapted for accommodating a pharmaceutical container, a filling unit adapted for filling the active pharmaceutical ingredient into the pharmaceutical capsule, and a controller adapted for controlling the amount of the active pharmaceutical ingredient filled into the pharmaceutical capsule,. Further, a pharmaceutical container is described. Moreover, a kit comprising the device for preparing a filled pharmaceutical capsule on demand and the pharmaceutical container is described. Furthermore, a method for preparing a filled pharmaceutical capsule on demand with a predetermined amount of an active pharmaceutical ingredient is described.
Abstract translation: 描述了一种根据需要用预定量的活性药物成分制备填充药物胶囊的装置。 该装置包括适于容纳药物容器的容器容纳单元，适于将活性药物成分填充到药物胶囊中的填充单元，以及适于控制填充到药物胶囊中的活性药物成分的量的控制器。 此外，描述了药物容器。 此外，描述了包括用于根据需要制备填充的药物胶囊的装置和药物容器的试剂盒。 此外，描述了按预定量的活性药物成分制备填充药物胶囊的方法。
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10.发明申请VOLATILE ORGANIC COMPOUNDS FROM BACTERIAL ANTAGONISTS FOR CONTROLLING MICROBIAL GROWTH 审中-公开用于控制微生物生长的细菌拮抗剂的挥发性有机化合物
公开(公告)号：WO2012085255A2
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073891
申请日：2011-12-22
Applicant: RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , AICHNER, Martin , OBERAUNER, Lisa , LIEBMINGER, Stefan , FÜRNKRANZ, Michael , KLEIN, Thomas , KHINAST, Johannes , BERG, Gabriele
Inventor： AICHNER, Martin , OBERAUNER, Lisa , LIEBMINGER, Stefan , FÜRNKRANZ, Michael , KLEIN, Thomas , KHINAST, Johannes , BERG, Gabriele
CPC classification number: D06M16/003 , A01N43/60 , A01N63/00 , A01N63/02 , A01N63/04 , A01N65/00 , A01N65/08 , A01N65/34 , A01N65/38 , D06M16/00
Abstract: The present invention relates to methods and compositions for controlling microbial growth on a surface to be treated. More particularly, the invention is directed to a corresponding method comprising contacting the surface to be treated with one or more antimicrobial agents; and incubating the surface for a pre-selected period of time, wherein the one or more antimicrobial agents are volatile organic compounds produced by plant-associated microorganisms. In further aspects, the invention relates to a kit-of-parts and a composition, respectively, each comprising one or more volatile organic compounds produced by plantassociated microorganisms as defined herein.
Abstract translation: 本发明涉及用于控制待处理表面上的微生物生长的方法和组合物。 更具体地说，本发明涉及相应的方法，包括使待处理的表面与一种或多种抗微生物剂接触; 以及将所述表面孵育预选的时间段，其中所述一种或多种抗微生物剂是由植物相关微生物产生的挥发性有机化合物。 在另外的方面，本发明涉及各自的试剂盒和组合物，其各自包含由本文定义的植物相关微生物产生的一种或多种挥发性有机化合物。
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