公开(公告)号：WO2004043233A3

公开(公告)日：2005-03-31

申请号：PCT/US0335690

申请日：2003-11-07

Applicant: ROTHENBERG SHELDON P ,  DA COSTA MARIA ,  SEQUEIRA JEFFREY

Inventor： ROTHENBERG SHELDON P ,  DA COSTA MARIA ,  SEQUEIRA JEFFREY

IPC: A61B20060101 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  G01N33/536 ,  G01N33/564 ,  G01N33/567 ,  G01N33/82

CPC classification number: G01N33/564 ,  G01N33/82 ,  G01N2500/00 ,  G01N2800/24

Abstract: The present invention identifies autoantibodies to folate receptors. Methods to identify these autoantibodies to the human folate receptors are also provided. The present invention also contemplates diagnostic methods and test kits to be used in a clinical setting for identifying a subject at risk of folate-sensitive abnormalities or disorders as observed in neural tube defect complicatedpregnancies. In addition, infertility, spontaneous abortion, male sterility, unsuccessful in vitro fertilization,neurologic disorders and impaired folate absorption may also be associated with these autoantibodiesto folate receptors.

Abstract translation: 本发明鉴定了叶酸受体的自身抗体。 还提供了鉴定人叶酸受体的这些自身抗体的方法。 本发明还考虑用于临床设置中用于鉴定在神经管缺陷复杂妊娠中观察到的具有叶酸敏感性异常或障碍风险的受试者的诊断方法和测试试剂盒。 此外，不孕不育，自然流产，雄性不育，体外受精失败，神经系统疾病和叶酸受体受损也可能与这些自身抗体对叶酸受体有关。