利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1336 条记录 (耗时 0.018 秒)

    COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS
    5.
    发明申请
    COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
    组合物，与乳腺特异性基因和蛋白相关的差异变异和方法

    公开(公告)号：WO2005044075A3

    公开(公告)日：2009-04-02

    申请号：PCT/US2004030719

    申请日：2004-09-20

    申请人： DIADEXUS INC ,  MACINA ROBERTO A ,  TURNER LEAH R ,  SUN YONGMING

    发明人： MACINA ROBERTO A ,  TURNER LEAH R ,  SUN YONGMING

    IPC分类号： C07H21/02 ,  A61B20060101 ,  A61K31/70 ,  C07H21/04

    CPC分类号： C07K14/47 ,  C12Q1/6876

    摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

    摘要翻译： 本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

    ENDO 180 RECEPTOR FOR DIAGNOSIS AND TREATMENT
    6.
    发明申请
    ENDO 180 RECEPTOR FOR DIAGNOSIS AND TREATMENT 审中-公开
    第180号接受诊断和治疗的受试者

    公开(公告)号：WO2004100759A3

    公开(公告)日：2009-03-12

    申请号：PCT/IL2004000423

    申请日：2004-05-18

    申请人： QUARK BIOTECH INC ,  MOR ORNA ,  FEINSTEIN ELENA ,  FAERMAN ALEXANDER

    发明人： MOR ORNA ,  FEINSTEIN ELENA ,  FAERMAN ALEXANDER

    IPC分类号： G01N33/53 ,  A61B20060101 ,  C07H21/04 ,  C12P21/06 ,  G01N33/50 ,  G01N33/68

    CPC分类号： G01N33/5032 ,  G01N33/6872 ,  G01N2333/4724 ,  G01N2333/78

    摘要： This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of a compound, and determining whether the binding of the ENDO180 receptor to the interactor is affected by the compound. This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular fibrosis. This application also relates to the use of ENDO 180 modulators in treatment of disease.

    摘要翻译： 本申请涉及鉴定能够调节人ENDO180受体活性的化合物的方法，该方法包括以下步骤：在不存在或存在下测量ENDO180受体与ENDO180受体在体内特异性相互作用的相互作用因子的结合 的化合物，并确定ENDO180受体与相互作用体的结合是否受化合物的影响。 本申请还涉及通过该方法鉴定的化合物在制备用于治疗疾病，特别是纤维化的药物中的用途。 本申请还涉及使用ENDO 180调节剂治疗疾病。

    VERTEBRAL STABILIZATION ASSEMBLY AND METHOD
    9.
    发明申请
    VERTEBRAL STABILIZATION ASSEMBLY AND METHOD 审中-公开
    VERTEBRAL STABILIZATION ASSEMBLY和方法

    公开(公告)号：WO2007089846A3

    公开(公告)日：2008-01-24

    申请号：PCT/US2007002648

    申请日：2007-01-30

    申请人： VAUGHAN MEDICAL TECHNOLOGIES I ,  VAUGHAN PAUL A

    发明人： VAUGHAN PAUL A

    IPC分类号： A61B17/70 ,  A61B20060101 ,  A61B17/17 ,  A61B17/56 ,  A61B17/58 ,  A61B17/88 ,  A61B19/00

    CPC分类号： A61B17/1757 ,  A61B17/1735 ,  A61B17/70 ,  A61B17/7001 ,  A61B17/7059 ,  A61B17/7082 ,  A61B17/8875 ,  A61B90/36 ,  A61B2017/8655

    摘要： A vertebral stabilization assembly for stabilizing vertebrae is disclosed. In one exemplary embodiment, the assembly comprises a first vertebral screw having a shaft with a threaded portion and an engaging portion, a second vertebral screw having a shaft with a threaded portion and an engaging portion, a first connecting screw having a first end configured to be engaged by the engaging portion of the first vertebral screw, a second connecting screw having a first end configured to be engaged by the engaging portion of the second vertebral screw, a first horizontal connecting member configured to be coupled to the first vertebral screw and the first connecting screw, a second horizontal connecting member configured to be coupled to the second vertebral screw and the second connecting screw, and a vertical connecting member configured to be coupled to the first horizontal connecting member and the second horizontal connecting member.

    摘要翻译： 公开了一种用于稳定椎骨的椎骨稳定组件。 在一个示例性实施例中，组件包括具有带有螺纹部分和接合部分的轴的第一椎骨螺钉，具有带螺纹部分的轴和接合部分的第二椎骨螺钉，第一连接螺钉，其具有构造成 由第一椎骨螺钉的接合部分接合，第二连接螺钉，其具有构造成与第二椎骨螺钉的接合部分接合的第一端;第一水平连接构件，其构造成联接到第一椎骨螺钉， 第一连接螺钉，被配置为联接到第二椎骨螺钉和第二连接螺钉的第二水平连接构件，以及构造成联接到第一水平连接构件和第二水平连接构件的垂直连接构件。

    TRANSDUCER FOR SENSING BODY SOUNDS
    10.
    发明申请
    TRANSDUCER FOR SENSING BODY SOUNDS 审中-公开
    用于传感身体的传感器

    公开(公告)号：WO2004058054A3

    公开(公告)日：2007-12-27

    申请号：PCT/US0341422

    申请日：2003-12-23

    申请人： SMITH CLIVE

    发明人： SMITH CLIVE

    IPC分类号： A61B7/04 ,  A61B20060101 ,  A61B5/02 ,  A61B5/08 ,  A61B7/02 ,  H04R1/46 ,  H04R19/01

    CPC分类号： H04R19/016 ,  A61B7/04 ,  A61B2560/0209 ,  A61B2562/0204 ,  H04R1/46

    摘要： An acoustic-to-electrical transducer (152) for sensing body sounds is disclosed. The transducer (152) comprises a diaphragm (2/202) that can be placed in direct contact with a body, whereby the diaphragm motion directly affects an electromagnetic sensing signal, which is then converted to an electrical signal representation of the diaphragm motion. Such sensing means (70) allows the diaphragm (2/202) to move freely without mechanical coupling to a secondary transducer, while providing a direct and further provides a means for using static diaphragm pressure to control gain and frequency characteristics of the electrical signal. The transducer provides methods for ambient noise reduction or applications such as well as means for simulating sound detection for applications such as medical education and testing. The sensor, circuitry, manufacturing methods and improvements are disclosed.

    摘要翻译： 公开了一种用于感测身体声音的声 - 电传感器（152）。 换能器（152）包括可以放置成与身体直接接触的隔膜（2/202），由此隔膜运动直接影响电磁感测信号，然后电磁感测信号被转换成隔膜运动的电信号表示。 这种感测装置（70）允许膜片（2/202）在没有机械耦合到二次换能器的情况下自由移动，同时提供直接并且进一步提供使用静态隔膜压力来控制电信号的增益和频率特性的装置。 传感器提供环境降噪或应用的方法，例如用于模拟医学教育和测试等应用的声音检测的手段。 公开了传感器，电路，制造方法和改进。