公开(公告)号：WO2016201243A1

公开(公告)日：2016-12-15

申请号：PCT/US2016/036914

申请日：2016-06-10

Applicant: SAINT LOUIS UNIVERSITY ,  THE CITY UNIVERSITY OF NEW YORK

Inventor： TAVIS, John, Edwin ,  MORRISON, Lynda, Anne ,  MURELLI, Ryan, P.

IPC: A61K31/122 ,  C07C49/717 ,  C07C49/733

CPC classification number: A61K31/122 ,  A61K31/513 ,  A61K31/522 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/708 ,  A61K38/212 ,  A61K45/06 ,  C07C49/717 ,  C07C49/733 ,  C07C69/757 ,  C07C2601/14 ,  C07C2601/18 ,  A61K2300/00

Abstract: The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.

Abstract translation: 本公开涉及疱疹病毒核酸代谢抑制剂和乙型肝炎病毒抑制剂。 还提供了使用这些药剂的治疗方法。

公开(公告)号：WO2019118803A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/065601

申请日：2018-12-14

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK ON BEHALF OF BROOKLYN COLLEGE

Inventor： LE GRICE, Stuart, F.J. ,  SZTUBA-SOLINSKA, Joanna ,  MURELLI, Ryan, P.

IPC: A61K31/122 ,  A61K31/235 ,  A61K31/365 ,  A61K31/473 ,  A61K31/496 ,  A61P31/22

CPC classification number: A61K31/473 ,  A61K31/122 ,  A61K31/235 ,  A61K31/365 ,  A61K31/496 ,  A61P31/22 ,  A61K2300/00

Abstract: A method for activating and killing Kaposi's sarcoma herpesvirus (KSHV) includes (i) contacting latent KSHV with an amount of a compound according to Formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, effective to activate at least some of the latent KSHV, and (ii) contacting the activated KSHV with an amount of an α-hydroxytropolone effective to kill at least some of the activated KSHV. With respect to Formula I, R 1 is -N(R 2 )-C(0)-(CH 2 ) x -R 3 where R 2 is hydrogen or C 1 -C 3 alkyl, R 3 is a substituted amino group or a substituted or unsubstituted piperazinyl or piperidinyl group, and x is an integer from 0-10.