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    APPLICATIONS OF OPTICAL DETECTION OF LOW-LEVEL CHEMICAL AND BIOLOGICAL SUBSTANCES BY NONLINEAR LASER WAVE MIXING IN MEDICINE AND FOOD SAFETY
    2.
    发明申请
    APPLICATIONS OF OPTICAL DETECTION OF LOW-LEVEL CHEMICAL AND BIOLOGICAL SUBSTANCES BY NONLINEAR LASER WAVE MIXING IN MEDICINE AND FOOD SAFETY 审中-公开
    非线性激光波混合在医药和食品安全中低浓度化学和生物物质的光学检测应用

    公开(公告)号：WO2017143347A1

    公开(公告)日：2017-08-24

    申请号：PCT/US2017/018752

    申请日：2017-02-21

    申请人： SAN DIEGO STATE UNIVERSITY FOUNDATION

    发明人： TONG, William, G.

    IPC分类号： G01N33/49 ,  G01N21/63 ,  G01N33/58 ,  G01N35/08

    CPC分类号： G01N21/636 ,  G01N21/72 ,  G01N21/73 ,  G01N21/74 ,  G01N27/447 ,  G01N33/49 ,  G01N33/58 ,  G01N33/6896 ,  G01N35/08 ,  G01N2021/0346 ,  G01N2021/6439 ,  G01N2201/0221 ,  G01N2201/08 ,  G01N2800/2835 ,  G01N2800/56

    摘要： This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring α-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing α-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four- wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the α-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the α-synuclein in the fluidic sample.

    摘要翻译： 该专利文件公开了用于使用光学非线性波混合来检测目标物质的技术，系统和设备，以提高检测灵敏度和准确度。 一方面，提供了用于以高检测灵敏度和准确度测量患者体液中的α-突触核蛋白并提供早期帕金森病检测的方法。 该方法可以包括：向毛细管分析物池提供包含含有α-突触核蛋白的患者的体液的流体样品，其中毛细管分析物池位于非线性光学四波混合装置中; 将来自非线性光学四波混合装置的激光引导到毛细管分析物单元中以引起流体样品中的非线性光学四波混合以产生包含关于流体样品中的α-突触核蛋白的信息的四波混合信号; 并处理四波混合信号以提取关于流体样品中的α-突触核蛋白的信息。