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    DEVICES, SYSTEMS, AND METHODS FOR ILLUMINATING AND IMAGING OBJECTS
    1.
    发明申请
    DEVICES, SYSTEMS, AND METHODS FOR ILLUMINATING AND IMAGING OBJECTS 审中-公开
    用于照明和成像对象的装置，系统和方法

    公开(公告)号：WO2018070938A1

    公开(公告)日：2018-04-19

    申请号：PCT/SG2017/050512

    申请日：2017-10-12

    Applicant: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED

    Inventor： CHEN, Mingsong ,  SHI, Benyong ,  TOH, Tiong Han ,  YEO, Steven

    IPC: G02B21/06 ,  G02B21/36 ,  G01N21/64

    CPC classification number: G02B27/14 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G02B6/04 ,  G02B17/02 ,  G02B21/06 ,  G02B21/362 ,  G02B26/0816 ,  G02B27/1066 ,  G02B27/108 ,  G02B27/16

    Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.

    Abstract translation: 照明系统包括被配置为具有放置在其上的成像目标的表面，光源，分束器和至少第一反射镜。 分束器被配置为分离来自光源的光束，并且第一反射镜被配置为将来自分束器的第一光束反射到具有成像目标的表面上。 成像系统包括被配置成具有放置在其上的成像目标的成像表面，镜子和捕捉装置。 捕捉设备被配置为通过从成像目标延伸的发射光的路径捕捉成像目标的图像，从镜子反射并捕捉到捕捉设备。 镜子，捕捉设备或两者被配置成相对于成像表面沿对角方向移动以减小发射光路径的长度。 校准成像系统以消除或减少由于成像系统特性导致的样品图像内的不均匀性的系统和方法。

    CUVETTE AND METHOD FOR MEASURING REFRACTIVE INDEX IN A SPECTROPHOTOMETER
    2.
    发明申请
    CUVETTE AND METHOD FOR MEASURING REFRACTIVE INDEX IN A SPECTROPHOTOMETER 审中-公开
    光谱仪和用于测量分光光度计中的折射率的方法

    公开(公告)号：WO2017129196A1

    公开(公告)日：2017-08-03

    申请号：PCT/DK2017/050018

    申请日：2017-01-26

    Applicant: DANMARKS TEKNISKE UNIVERSITET

    Inventor： KRISTENSEN, Anders ,  SØRENSEN, Kristian Tølbøl ,  HØJLUND-NIELSEN, Emil

    IPC: G01N21/77 ,  G01N21/25 ,  G01N21/41 ,  G02B1/00 ,  G02B6/122 ,  B01L3/00

    CPC classification number: G01N21/774 ,  G01N21/253 ,  G01N21/4133 ,  G02B1/005 ,  G02B2006/1213

    Abstract: Embodiments of the present invention include a cuvette (100) for use in determining a refractive index of a sample matter in a spectrophotometer (600), the cuvette comprising a container (102) for holding the sample matter, the container (102) having an entry window (121) that allows input radiation to reach the sample matter, the container furthermore having an exit window (122) that allows a part of the input radiation to exit the container part, the entry window and the exit window defining a radiation path; and comprising a photonic crystal (101) rigidly attached to the container or integrally formed in the container and arranged in the radiation path, the photonic crystal having a grating part (111) causing a reflectance spectrum of the photonic crystal to exhibit a resonance. A spectrophotometer is also provided.

    Abstract translation: 本发明的实施例包括用于确定分光光度计（600）中的样品物质的折射率的比色池（100），所述比色池包括容器（102），用于容纳样品物质 ，所述容器（102）具有允许输入辐射到达所述样本物质的入口窗口（121），所述容器还具有允许一部分输入辐射离开所述容器部分的出口窗口（122），所述入口窗口 并且出射窗限定辐射路径; 并且包括光子晶体（101），所述光子晶体（101）刚性地附接到所述容器或者一体地形成在所述容器中并且布置在所述辐射路径中，所述光子晶体具有引起所述光子晶体的反射光谱呈现谐振的光栅部分（111）。 还提供分光光度计。

    METHOD FOR CALIBRATING AND USING CALIBRATION OF MICROPLATES
    3.
    发明申请
    METHOD FOR CALIBRATING AND USING CALIBRATION OF MICROPLATES 审中-公开
    校准和使用微孔板校准的方法

    公开(公告)号：WO2017127719A1

    公开(公告)日：2017-07-27

    申请号：PCT/US2017/014392

    申请日：2017-01-20

    Applicant: IONFIELD HOLDINGS, LLC

    Inventor： HENSLEY, Paul, F.

    IPC: C12Q1/02 ,  C12Q1/68 ,  G01N21/17 ,  G01N33/48 ,  G01N33/50

    CPC classification number: B01L3/5085 ,  B01L3/545 ,  B01L2300/021 ,  B01L2300/022 ,  G01N21/253 ,  G01N21/274 ,  G01N21/6452 ,  G01N35/00693

    Abstract: A system and method to perform calibrated assays in reusable microplates, the method including steps of illuminating a microplate having wells and a microplate identifier, with a probe signal, detecting an uncalibrated return signal, reading the microplate identifier, retrieving, from a database by use of the microplate identifier, a calibration factor for each well in the microplate, calibrating the return signal for each well by use of the respective calibration factor for said well, and outputting the calibrated return signal as said calibrated assay. The system includes a microplate, comprising a plurality of wells and a microplate identifier, a reader to read the microplate identifier, a probe signal source and return signal detector, wherein a return signal comprises a probe signal after interaction with the plurality of wells, a calibration database to store the microplate identifier associated with return signal measurements, and a processor to perform the method.

    Abstract translation: 用于在可重复使用的微孔板中执行校准测定的系统和方法，所述方法包括以下步骤：用探针信号照射具有孔和微孔板标识物的微孔板，检测未校准的返回信号，读取微孔板标识符 ，通过使用微孔板标识符从数据库中检索微孔板中每个孔的校准因子，通过使用所述孔的相应校准因子校准每个孔的返回信号，并且输出校准的返回信号作为所述校准的 检测。 该系统包括：包含多个孔和微孔板标识物的微孔板，读取微孔板标识符的读数器，探针信号源和返回信号检测器，其中返回信号包括与多个孔相互作用后的探针信号， 校准数据库以存储与返回信号测量相关联的微孔板标识符，以及处理器执行该方法。

    SCREENING OF NUCLEIC ACID SEQUENCE VARIATIONS VIA RANDOM LOADING OF OPTICALLY-ENCODED PARTICLES
    4.
    发明申请
    SCREENING OF NUCLEIC ACID SEQUENCE VARIATIONS VIA RANDOM LOADING OF OPTICALLY-ENCODED PARTICLES 审中-公开
    通过光学加工颗粒的随机加载来筛选核酸序列变异

    公开(公告)号：WO2017035347A1

    公开(公告)日：2017-03-02

    申请号：PCT/US2016/048687

    申请日：2016-08-25

    Applicant: THE BROAD INSTITUTE, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  FELDMAN, David ,  SAZER, Daniel ,  BLAINEY, Paul

    Inventor： FELDMAN, David ,  SAZER, Daniel ,  BLAINEY, Paul

    IPC: C12P19/34 ,  C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/6844 ,  B01L3/502761 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/65 ,  C12Q2563/155 ,  C12Q2563/159 ,  C12Q2565/514

    Abstract: Embodiments disclosed herein provide reagents and methods for high-throughput screening of nucleic acid sequence variations in nucleic acid containing specimens. Nucleic acid specimens to be screened are loaded into separate discrete volumes. Optically encoded particles are used to deliver primers to amplify one or more sequences comprising the nucleic acid sequence variation. The optically encoded particles may be delivered to the discrete volumes randomly resulting in a random combination of optically encoded particles in each well, or a unique combination of optically encoded particles may be specifically assigned to each discrete volume. The observable combination of optically encoded particles may then be used to identify each discrete volume.

    Abstract translation: 本文公开的实施方案提供了用于高通量筛选含核酸标本中核酸序列变异的试剂和方法。 要筛选的核酸标本被加载到单独的离散体积中。 光学编码的颗粒用于递送引物以扩增包含核酸序列变异的一个或多个序列。 光学编码的颗粒可以随机地输送到离散的体积，导致每个孔中光学编码的颗粒的随机组合，或者光学编码的颗粒的独特组合可以具体地分配给每个离散的体积。 然后可以使用光学编码的颗粒的可观察组合来识别每个离散体积。

    TEST APPARATUS AND CONTROL METHOD THEREOF
    7.
    发明申请
    TEST APPARATUS AND CONTROL METHOD THEREOF 审中-公开
    测试装置及其控制方法

    公开(公告)号：WO2016088992A1

    公开(公告)日：2016-06-09

    申请号：PCT/KR2015/009819

    申请日：2015-09-18

    Applicant: SAMSUNG ELECTRONICS CO., LTD.

    Inventor： YEO, Yeong Bae

    IPC: G01N21/78 ,  G01N21/27 ,  G01N21/59

    CPC classification number: G01N21/78 ,  G01N21/07 ,  G01N21/253 ,  G01N2021/0325 ,  G01N2021/7783

    Abstract: A test apparatus and a control method thereof are provided. The test apparatus is configured to test a sample in a reactor. The test apparatus includes a light emitter configured to emit light to chambers of the reactor, a light receiver configured to receive light passed through the chambers while scanning the chambers, and a processor configured to determine a position or an area of a chamber among the chambers, based on light receiving positions of the light receiver, and respective intensities of the received light. The processor is further configured to measure an optical density of light passed through the determined position or the determined area of the chamber.

    Abstract translation: 提供了一种测试装置及其控制方法。 测试装置被配置为在反应器中测试样品。 测试装置包括被配置为向反应器的室发射光的光发射器，配置成在扫描室时接收通过腔室的光的光接收器，以及被配置为确定腔室在腔室中的位置或面积的处理器 ，基于光接收器的光接收位置，以及接收光的相应强度。 处理器还被配置为测量通过所确定的位置或确定的腔室区域的光的光密度。

    COLORIMETRIC GAS MONITORING SYSTEM WITH STORAGE MAGAZINE FOR DISPOSABLE TEST ELEMENTS
    10.
    发明申请
    COLORIMETRIC GAS MONITORING SYSTEM WITH STORAGE MAGAZINE FOR DISPOSABLE TEST ELEMENTS 审中-公开
    具有存储杂质的彩色气体监测系统，用于可弃置的测试元件

    公开(公告)号：WO2015053795A1

    公开(公告)日：2015-04-16

    申请号：PCT/US2013/064691

    申请日：2013-10-11

    Applicant: DRAEGER SAFETY, INC.

    Inventor： EDWARDS, Sam, M. ,  MURAJDA, Gary, F.

    IPC: G01N33/00 ,  G01N21/25 ,  G01N21/78 ,  G01N35/00 ,  G01N35/02

    CPC classification number: G01N21/253 ,  G01N1/2273 ,  G01N21/783 ,  G01N31/22 ,  G01N35/00029 ,  G01N2035/00089

    Abstract: Described herein is a gas monitoring system including a measuring component having a first housing containing a colorimeter in an internal volume of the first housing. The system includes a storage magazine having a second housing with an internal volume surrounded by a base plate positioned opposite an upper plate, a first side panel having a first slot and a second side panel having a second slot. The storage magazine has a follower within the internal volume of the second housing suspended from the upper plate by a spring element that biases the follower toward the base plate and away from the upper plate. The system includes an actuator coupled to the first housing having a pusher ram loader arm engaged with a motor. Related apparatus, systems, methods and/or articles are described.

    Abstract translation: 这里描述了一种气体监测系统，其包括测量部件，其具有在第一壳体的内部容积中包含色度计的第一壳体。 该系统包括具有第二壳体的存储盒，第二壳体具有由与上板相对定位的底板包围的内部容积，具有第一槽的第一侧板和具有第二槽的第二侧板。 存储盒具有在第二壳体的内部体积内的随动件，其通过弹簧元件从上板悬挂，该弹簧元件将随动件朝向底板偏压并远离上板。 该系统包括联接到第一壳体的致动器，其具有与电动机接合的推动器活塞装载臂。 描述了相关装置，系统，方法和/或制品。

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