公开(公告)号：WO2016001293A1

公开(公告)日：2016-01-07

申请号：PCT/EP2015/064967

申请日：2015-07-01

Applicant: SANOFI

Inventor： MARSH, William ,  MORRIS, Anthony Paul ,  BUTLER, Joseph ,  JONES, Matthew

IPC: A61M5/315 ,  A61M5/31

CPC classification number: A61M5/20 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M2005/2026 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582

Abstract: The present invention is generally directed to an injection device for selecting and dispensing a number of user variable doses of a medicament. The injection device comprises a housing (10) having a longitudinal axis (I), a dose setting member (60; 80) rotatable relative to the housing (10) during dose setting, a drive member (40) which is rotationally constrained to the housing (10) in a first dose setting mode and which is rotatable relative to the housing (10) in a second dose dispensing mode, a locking element (100) which is permanently rotationally constrained to the housing (10) and movable relative to the housing (10) in a direction parallel to the longitudinal axis (I) between a first dose setting position and a second dose dispensing position, an actuation button (70) movable relative to the housing (10) in a direction parallel to the longitudinal axis (I) between a first dose setting position and a second dose dispensing position for switching the injection device between the first dose setting mode and the second dose dispensing mode, a ratchet (42, 120) for transmitting torque from the dose setting member (60) to the drive member (40) during dose dispensing and allowing relative rotational movement between the dose setting member (60) and the drive member (40) during dose setting, the ratchet (42, 120) comprising first ratchet features (43) rotationally constrained to the driver (40) and second ratchet features (121) rotationally constrained to the dose setting member (60), and a spring (130). The spring (130) biases the locking element (100) and the actuation button (70) into their first dose setting position and biases the first ratchet features (43) into engagement with the second ratchet features (121).

Abstract translation: 本发明一般涉及用于选择和分配多个用户可变剂量的药物的注射装置。 注射装置包括具有纵向轴线（I）的壳体（10），剂量设定期间相对于壳体（10）可旋转的剂量设定构件（60; 80），驱动构件（40），其被旋转地约束到 壳体（10）以第一剂量设定模式并且可以以第二剂量分配模式相对于壳体（10）旋转;锁定元件（100），其永久地旋转地约束到壳体（10）并且可相对于壳体 壳体（10）在平行于纵向轴线（I）的方向上在第一剂量设定位置和第二剂量分配位置之间，致动按钮（70）可在平行于纵向轴线的方向上相对于壳体（10）移动 （I）在第一剂量设定位置和第二剂量分配位置之间，用于在第一剂量设定模式和第二剂量分配模式之间切换注射装置，用于从剂量设定构件（60）传递扭矩的棘轮（42,120） ）到t 他在剂量分配期间驱动构件（40），并且在剂量设定期间允许剂量设定构件（60）和驱动构件（40）之间的相对旋转运动，棘轮（42,120）包括旋转地限制在 驱动器（40）和旋转地约束到剂量设定构件（60）的第二棘轮特征（121）以及弹簧（130）。 弹簧（130）将锁定元件（100）和致动按钮（70）偏压到其第一剂量设定位置，并且将第一棘轮特征（43）偏置成与第二棘轮特征（121）接合。

公开(公告)号：WO2014166912A1

公开(公告)日：2014-10-16

申请号：PCT/EP2014/056994

申请日：2014-04-08

Applicant: SANOFI

Inventor： BUTLER, Joseph ,  JONES, Matthew ,  PLUMPTRE, David Aubrey ,  MARSH, William ,  VEASEY, Robert

IPC: A61M5/315

CPC classification number: A61M5/31528 ,  A61M5/20 ,  A61M5/31541 ,  A61M5/3155 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M5/31591 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582

Abstract: The invention refers to a handheld injection device comprising a housing (10), a rotatable dose setting member (80, 60), a power reservoir (90) coupled to the dose setting member wherein energy is stored in the power reservoir during rotation of the dose setting member, a release member (70) for receiving a force from a user, and a rotatably arranged drive member (40) engaging with a drive track (32) of a piston rod (30). The device further comprises a release clutch (100; 230) rotationally constrained to the housing and releasably engaging the drive member, wherein the release clutch is positionable in a first axial position when the release member is in a dose setting position and in a second axial position when the release member is in a dose injection position. The axial position of the drive member within the housing remains constant when the release member is in its dose setting position and in its dose injection position.

Abstract translation: 本发明涉及一种手持式注射装置，其包括壳体（10），可旋转的剂量设定构件（80,60），联接到剂量设定构件的电力储存器（90），其中，在所述电力储存器 剂量设定构件，用于接收来自使用者的力的释放构件（70）和与活塞杆（30）的驱动轨道（32）接合的可旋转地布置的驱动构件（40）。 该装置还包括旋转地约束到壳体并可释放地接合驱动构件的释放离合器（100; 230），其中当释放构件处于剂量设定位置时，释放离合器可定位在第一轴向位置，并且在第二轴向 当释放构件处于剂量注射位置时的位置。 当释放构件处于其剂量设定位置和剂量注射位置时，驱动构件在壳体内的轴向位置保持恒定。

公开(公告)号：WO2017085090A1

公开(公告)日：2017-05-26

申请号：PCT/EP2016/077796

申请日：2016-11-16

Applicant: SANOFI

Inventor： MARSH, William

IPC: A61M5/20 ,  A61M5/315

CPC classification number: A61M5/20 ,  A61M5/31553 ,  A61M5/31583

Abstract: A drug delivery device for dispensing a dose of a liquid medicament with a rotationally driveable expelling mechanism adapted to expel the dose of the liquid medicament from a medicament container, a round torsional drive spring adapted to apply a driving torque to the rotationally driveable expelling mechanism when energized by an external strain, wherein the round torsional drive spring encloses an interior space of varying shape and/or extension according to the level of external strain applied to the round torsional drive spring, and at least one restraining element defining a number of rest surfaces to internally support the round torsional drive spring increasingly with the level of external strain applied thereto, can be improved by providing the rest surfaces with an outer shape as to essentially maintain the centre of the interior space throughout the entire variation in external strain applicable to the round torsional drive spring.

Abstract translation: 一种用于分配一定剂量的液体药物的药物输送装置，该药物输送装置具有可旋转驱动的排出机构，该排出机构适于从药物容器排出液体药物的剂量，圆形扭转驱动弹簧适于施加驱动 所述圆形扭转驱动弹簧在由外部应变激励时向所述可旋转驱动的排出机构施加扭矩，其中，所述圆形扭转驱动弹簧根据施加至所述圆形扭转驱动弹簧的外部应变的水平而包围变化形状和/或延伸的内部空间，并且至少一个 限制元件限定多个支承表面以通过施加到其上的外部应变水平而内部地支撑圆形扭转驱动弹簧的内部支承元件可以通过提供具有外部形状的休止表面以改善内部空间的中心， 适用于圆形扭转驱动弹簧的外部应变的全部变化。

公开(公告)号：WO2016055624A3

公开(公告)日：2016-04-14

申请号：PCT/EP2015/073429

申请日：2015-10-09

Applicant: SANOFI

Inventor： MARSH, William ,  MORRIS, Anthony Paul ,  BUTLER, Joseph ,  JONES, Matthew ,  STEEL, Samuel ,  AVERY, Richard James Vincent

IPC: A61M5/20 ,  A61M5/315

Abstract: The present invention relates to a drive mechanism which is suitable for an injection device, especially a pen type drug delivery device and to such a drug delivery device. The mechanism comprises a spring driven rotatable drive member (120), a rotatable driven member (40), a clutch (41, 121) rotationally coupling the driven member (40) and the drive member (120) in a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member (40) and the drive member (120) in a decoupled state, and a spring (130) biasing the clutch (41, 121) into its coupled state and allowing relative axial movement between the drive member (120) and the driven member (40) into the decoupled state of the clutch () against the bias of the spring (130). The clutch comprises a first ring of crown teeth (121) on the drive member (120) and a second ring of corresponding crown teeth (41) on the driven member (40) with each crown tooth (41, 121) having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth (41, 121) are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction. The material of the drive member (120) may be polybutylene terephthalate (PBT) or polyoxymethylene (POM) and the material of the rotatable driven member (40) may be PBT, POM or polycarbonate (PC). Further, the coefficient of friction (µ) between the teeth (41, 121) may be between 0.07 and 0.13 and the teeth (41, 121) may have a surface roughness (Ra) between 0.5 and 1.2.

公开(公告)号：WO2016055621A1

公开(公告)日：2016-04-14

申请号：PCT/EP2015/073424

申请日：2015-10-09

Applicant: SANOFI

Inventor： MARSH, William ,  MORRIS, Anthony Paul ,  JONES, Matthew ,  STEEL, Samuel

IPC: A61M5/20 ,  A61M5/24 ,  A61M5/315

CPC classification number: A61M5/31573 ,  A61M5/2033 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31561 ,  A61M5/31583 ,  A61M5/31585 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2026 ,  A61M2005/2407 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2207/00

Abstract: The present invention is generally directed to a method for assembling a drive spring (90), especially into a drug delivery device, comprising the steps of rotating a component part (60a) to which the drive spring (90) is attached in a first direction, followed by a rotation of the component part (60a) in the opposite direction and followed by attachment of a rotational stop (60b, 62). Further, the invention is directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre- charged drive spring (90).

Abstract translation: 本发明一般涉及一种用于组装驱动弹簧（90）的方法，特别是将其装配到药物输送装置中，包括以下步骤：使驱动弹簧（90）的第一方向 ，随后部件部件（60a）沿相反方向旋转，然后安装旋转止动件（60b，62）。 此外，本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置，该装置包括预充电的驱动弹簧（90）。

公开(公告)号：WO2016001298A1

公开(公告)日：2016-01-07

申请号：PCT/EP2015/064977

申请日：2015-07-01

Applicant: SANOFI

Inventor： MARSH, William

IPC: A61M5/315 ,  A61M5/31

CPC classification number: A61M5/31553 ,  A61M5/20 ,  A61M5/31526 ,  A61M5/31536 ,  A61M5/31541 ,  A61M5/3156 ,  A61M5/31585 ,  A61M5/31593 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2005/3154 ,  A61M2205/3379 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2207/00

Abstract: The present invention is generally directed to an injection device for setting and dispensing a number of user variable doses of a medicament and a method of assembling same. The injection device comprises a housing (10) having a longitudinal axis (I), a dose setting member (60; 80) rotatable relative to the housing (10) during dose setting, and a torsion spring (90) which is strained during dose setting and which is attached with its first end to the housing (10) and with its second end (91) to the dose setting member (60; 80). The dose setting member (60; 80) comprises a guide or groove(68) with side walls having the form of a ring segment for receiving the second end (91) of the spring (90) and a non-return feature (69a, 69c) for anchoring the second end (91) of the spring (90) within the guide or groove (68) and/or an end feature (69b, 69d) located within the guide or groove(68) such that it pushes the second end (91) of the spring into contact with a side wall of the guide or groove (68).

Abstract translation: 本发明一般涉及用于设置和分配多个用户可变剂量的药物的注射装置及其组装方法。 注射装置包括具有纵向轴线（I）的壳体（10），在剂量设定期间相对于壳体（10）可旋转的剂量设定构件（60; 80）和在剂量期间应变的扭转弹簧（90） 并且其第一端附接到壳体（10）并且其第二端（91）附接到剂量设定构件（60; 80）。 剂量设定构件（60; 80）包括导向槽或凹槽（68），侧壁具有用于接收弹簧（90）的第二端（91）的环形段的形式，以及不返回特征（69a， 69c），用于将弹簧（90）的第二端（91）固定在位于引导件或凹槽（68）内的引导件或凹槽（68）和/或端部特征（69b，69d）内，使得其推动第二 弹簧的端部（91）与引导件或凹槽（68）的侧壁接触。

公开(公告)号：WO2014166924A1

公开(公告)日：2014-10-16

申请号：PCT/EP2014/057006

申请日：2014-04-08

Applicant: SANOFI

Inventor： MARSH, William ,  MORRIS, Anthony Paul ,  BUTLER, Joseph ,  JONES, Matthew

IPC: A61M5/315

CPC classification number: A61M5/3159 ,  A61M5/20 ,  A61M5/31528 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M5/31586 ,  A61M5/31593 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583

Abstract: The invention refers to a handheld injection device comprising a housing (10; 410)and a dose indicator (90; 480) positioned within and axially constrained to the housing (10; 410) and rotatable with respect to the housing (10; 410) during dose setting and during dose dispensing. The dose indicator (90; 480) may comprise a flexible clicker arm (95; 482) which, only during dispense, is displaced in a first radial direction and, when the device reaches its minimum dose (zero) position, in a second, opposite radial direction.

Abstract translation: 本发明涉及一种手持式注射装置，其包括定位在壳体（10; 410）内且轴向限制于壳体（10; 410）并可相对于壳体（10; 410）旋转的壳体（10; 410）和剂量指示器（90; 480） 在剂量设定期间和剂量分配期间。 剂量指示器（90; 480）可以包括柔性拨号臂（95; 482），其仅在分配期间在第一径向方向上移位，并且当装置达到其最小剂量（零）位置时， 径向相反。

公开(公告)号：WO2014166922A2

公开(公告)日：2014-10-16

申请号：PCT/EP2014/057004

申请日：2014-04-08

Applicant: SANOFI

Inventor： MARSH, William ,  MORRIS, Anthony Paul ,  BUTLER, Joseph ,  JONES, Matthew

IPC: A61M5/315

CPC classification number: A61M5/31583 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/3155 ,  A61M5/31553 ,  A61M5/31561 ,  A61M5/31568 ,  A61M5/3157 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583

Abstract: The invention refers to a handheld injection device comprising a housing (10; 410), a dose indicator (90; 480) positioned within and axially constrained to the housing (10; 410) and rotatable with respect to the housing (10; 410) during dose setting and during dose dispensing, a gauge element (80; 490), which is at least partly interposed between the housing (10; 410) and the dose indicator (90; 480), wherein the gauge element (80; 490) is axially guided within the housing (10; 410) and in threaded engagement with the dose indicator (90; 480) such that rotation of the dose indicator (90; 480) causes an axial displacement of the gauge element (80; 490). A contrast element having a first marking is provided and at least a region of the gauge element (80; 490) is provided with a second marking, with the first marking and/or the second marking being visible through a first window (12a) or aperture in the housing (10; 410) depending on the axial position of the gauge element (80; 490) within the housing (10; 410).

Abstract translation: 本发明涉及一种手持式注射装置，其包括壳体（10; 410），位于壳体（10; 410）内且轴向约束于壳体（10; 410）并且可相对于其旋转的剂量指示器（90; 480） 在剂量设定期间和在剂量分配期间向壳体（10; 410）施加至少部分插入在壳体（10; 410）和剂量指示器（90; 480）之间的测量元件（80; 490），其中， 所述计量元件（80; 490）在所述壳体（10; 410）内轴向引导并与所述剂量指示器（90; 480）螺纹接合，使得所述剂量指示器（90; 480）的旋转引起所述 量规元件（80; 490）。 提供具有第一标记的对比元件，并且至少测量元件（80; 490）的一个区域设置有第二标记，其中第一标记和/或第二标记通过第一窗口（12a）可见或者 根据壳体（10; 410）内的测量元件（80; 490）的轴向位置确定壳体（10; 410）中的孔口的位置。

公开(公告)号：WO2017041971A1

公开(公告)日：2017-03-16

申请号：PCT/EP2016/068857

申请日：2016-08-08

Applicant: SANOFI

Inventor： MORRIS, Anthony Paul ,  MARSH, William ,  JONES, Matthew

IPC: A61M5/315

CPC classification number: A61M5/31583 ,  A61M5/31511 ,  A61M2207/00

Abstract: The invention provides a piston rod (1) configured to engage a housing (3) of a drug delivery device (2), wherein the piston rod (1) comprises an outer thread (1.1) that corresponds with an inner thread (3.1) of the housing (3), characterized by a support element (1.2) that is configured as a supplement thread section of the outer thread (1.1), - wherein the support element (1.2) comprises a lead-in (L1) for assembly of the drug delivery device (2) and - wherein the lead-in (L1) is distally spaced from another lead-in (L2) arranged on the distal outer thread end (1.1.1). The invention further provides a drug delivery device (2) comprising such a piston rod (1) and a method for assembling such a drug delivery device (2).

Abstract translation: 本发明提供了一种构造成接合药物输送装置（2）的壳体（3）的活塞杆（1），其中活塞杆（1）包括与内螺纹（3.1）相对应的外螺纹（1.1） 所述壳体（3）的特征在于被配置为所述外螺纹（1.1）的补充螺纹部分的支撑元件（1.2），其中所述支撑元件（1.2）包括用于组装所述外螺纹 药物输送装置（2）和 - 其中引入部分（L1）与布置在远端外螺纹端部（1.1.1）上的另一引入线（L2）远离间隔开。 本发明还提供了一种包括这种活塞杆（1）的药物输送装置（2）和用于组装这种药物输送装置（2）的方法。

公开(公告)号：WO2016001304A1

公开(公告)日：2016-01-07

申请号：PCT/EP2015/064984

申请日：2015-07-01

Applicant: SANOFI

Inventor： MARSH, William ,  MORRIS, Anthony Paul ,  BUTLER, Joseph ,  JONES, Matthew ,  STEEL, Samuel ,  AVERY, Richard James Vincent

IPC: A61M5/20 ,  A61M5/315

CPC classification number: A61M5/3157 ,  A61M5/20 ,  A61M5/3146 ,  A61M5/31511 ,  A61M5/31515 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/2026 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582

Abstract: The present invention is generally directed to a clicker arrangement for use in a drug delivery device and a drug delivery device comprising such a clicker arrangement. The arrangement comprises a first, rotatable element (60) and a second, non-rotatable element (110). One of the first element (60) and the second element (110) comprises a clicker arm (67) and the other of the first element (60) and the second element (110) comprises a cam (117). Upon relative rotation of the first element (60) and the second element (110) the clicker arm (67) is elastically deflectable by the cam (117) and relaxable upon disengagement with the cam (117) thereby generating an audible and/or tactile feedback signal. The arrangement further comprises a third, axially movable element (40) having a ramp (47) for interaction with the clicker arm (67), wherein, when the third element (40) is in a first axial position, the ramp (47) does not interact with the clicker arm (67), which in turn prevents the clicker arm (67) from contacting the cam (117), and when the third element (40) is in a second axial position, the ramp (47) deflects the clicker arm (67) such that the clicker arm (67) contacts the cam (117).

Abstract translation: 本发明总体上涉及一种用于药物递送装置的药水输送装置和包括这种鸣叫装置的药物输送装置。 该装置包括第一可旋转元件（60）和第二不可旋转元件（110）。 第一元件（60）和第二元件（110）中的一个包括答卷臂（67），第一元件（60）和第二元件（110）中的另一个包括凸轮（117）。 当第一元件（60）和第二元件（110）相对旋转时，答卷臂（67）可被凸轮（117）弹性偏转，并且在与凸轮（117）分离时可松弛，从而产生可听和/或触觉 反馈信号。 该装置还包括一个第三轴向可移动的元件（40），该元件具有一个用于与该答题器臂（67）相互作用的斜面（47），其中当该第三元件（40）处于第一轴向位置时，斜面（47） 不与答卷臂（67）相互作用，这又防止了答卷臂（67）接触凸轮（117），并且当第三元件（40）处于第二轴向位置时，斜面（47）偏转 （67）使得答卷臂（67）接触凸轮（117）。