公开(公告)号：WO2005081633A2

公开(公告)日：2005-09-09

申请号：PCT/IL2005/000234

申请日：2005-02-27

Applicant: SEGALESCU, Victor, A. ,  BARTAL, Gabriel

Inventor： SEGALESCU, Victor, A. ,  BARTAL, Gabriel

IPC: A61B18/18 ,  A61F2/958 ,  A61M29/02

CPC classification number: A61M25/1002 ,  A61B2017/22051 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/1086 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0609 ,  A61N2005/061 ,  A61N2005/0611

Abstract: An inflatable device to be used in treatment of stenotic lesions includes external optical fibers with a segment capable of emitting substantially uniform radial energy. The design of the optical fibers ensures a high optical coupling factor and a high efficiency in delivering light-energy to the adjacent tissue volume. A light source is connected to the optical fibers during the inflation of the device. The parameters of the light source: wavelength, waveform and intensity and the design of the optical fibers ensure that the light-tissue interaction depth is within a thin layer of stenotic lesion without inducing irreversible damage to the vessel wall. During the inflation of the device, the external optical fibers pressure the same tissue volume that interacted with the radial emitted light-energy. The confined radial light energy and the mechanical effects induced by the optical fibers create an opto-mechanical effect that facilitates the dilatation of stenotic lesions and reduces the risk of restenosis. The external optical fibers can also facilitate endoluminal drug activation, wherein light activated drugs are used to prevent restenosis or to treat cardiovascular, system, benign and malignant stenosis and other diseases. Various combinations of optical fibers with different capabilities can be used in the same device. The device can be used in treatment of stenosis in the vascular system and in non-vascular systems (such as the urinary or biliary systems). The design of the device ensures that the attachment of the external optical fibers does not obstruct the advancement and maneuvering of the device through tortuous anatomical structures such as stenotic or partially occluded blood vessels.

Abstract translation: 用于治疗狭窄病变的可充气装置包括具有能够发射基本均匀径向能量的节段的外部光纤。 光纤的设计确保高光耦合因子和高效的光能传递给相邻的组织体积。 在装置充气期间光源连接到光纤。 光源的参数：波长，波形和强度以及光纤的设计确保光 - 组织相互作用深度位于狭窄损伤薄层内，而不会对血管壁造成不可逆损伤。 在装置充气期间，外部光纤压迫与径向发射的光能相互作用的相同组织体积。 受限的径向光能和由光纤引起的机械效应产生光机械效应，促进狭窄病变的扩张并降低再狭窄的风险。 外部光纤也可以促进腔内药物活化，其中光活化药物用于预防再狭窄或治疗心血管系统，良性和恶性狭窄以及其他疾病。 具有不同能力的光纤的各种组合可以用于相同的设备中。 该装置可用于治疗血管系统和非血管系统（如泌尿系统或胆系统）的狭窄。 该设备的设计确保了外部光纤的连接不会通过曲折的解剖结构，如狭窄或部分闭塞的血管阻碍设备的前进和操纵。