公开(公告)号：WO2005103184A1

公开(公告)日：2005-11-03

申请号：PCT/JP2005/008391

申请日：2005-04-26

Applicant: SHOWA DENKO K. K. ,  ISHII, Tetsuya

Inventor： ISHII, Tetsuya

IPC: C09J133/06

CPC classification number: C08F6/16 ,  A61K9/7061 ,  A61L15/58 ,  A61L24/06 ,  C08F6/28 ,  C09J133/02 ,  C08L33/00

Abstract: The present invention provides an adhesive for a dermal patch comprising an acrylate-base polymer in which the repetitive unit is represented by the formulae (1), (2) and (3): wherein M represents NH 4 + or an alkali metal, and X represents an unsaturated monomer unit other than the formulae (1) and (2), containing 5 mole or more of acrylic acid (salt) represented by the formula (1) as a monomer unit, in which the content of ß-hydroxypropionic acid (salt) is 5,000 ppm or less per solid content of the polymer and having a stable shape retainability, adhesion and percutaneous absorptivity of medicines; an production process thereof; and an adhesive composition for a dermal patch containing the adhesive for a dermal patch, an aluminum compound and water.

Abstract translation: 本发明提供一种用于皮肤贴片的粘合剂，其包含丙烯酸酯基聚合物，其中重复单元由式（1），（2）和（3）表示：其中M表示NH 4 +或碱金属， X表示除式（1）和（2）以外的不饱和单体单元，其含有5摩尔以上的由式（1）表示的丙烯酸（盐）作为单体单元，其中β-羟基丙酸 每个固体含量的聚合物的酸（盐）为5000ppm以下，并且具有稳定的形状保持性，药物的粘附性和经皮吸收性; 其生产工艺; 以及用于皮肤贴剂的粘合剂组合物，其包含用于皮肤贴剂，铝化合物和水的粘合剂。

公开(公告)号：WO2004000918A1

公开(公告)日：2003-12-31

申请号：PCT/JP2003/007753

申请日：2003-06-18

Applicant: SHOWA DENKO K. K. ,  ISHII, Tetsuya

Inventor： ISHII, Tetsuya

IPC: C08J3/24

CPC classification number: A61K8/0212 ,  A61K8/042 ,  A61K8/676 ,  A61K8/8147 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/375 ,  A61K31/665 ,  A61K33/06 ,  A61K47/02 ,  A61K47/32 ,  A61K2800/594 ,  A61Q17/04 ,  A61Q19/00 ,  C08J3/075 ,  C08J2333/02 ,  A61K2300/00

Abstract: A hydrous gel substantially comprising at least two polymers selected from the group consisting of polyacrylic acid, sodium polyacrylate and partially neutralized polyacrylate, and water, the polymers being crosslinked by containing an aluminum compound, wherein the pH when the hydrous gel is 100-fold diluted with purified water is from 6.5 to 8.5. A hydrous gel which can stably hold an ascorbic acid or a derivative thereof, has high gel strength, exhibits good adhesion to an adherend and causes no liquid syneresis can be provided.

Abstract translation: 一种基本上包含至少两种选自聚丙烯酸，聚丙烯酸钠和部分中和的聚丙烯酸酯的聚合物和水的含水凝胶，所述聚合物通过含有铝化合物进行交联，其中当所述含水凝胶为100倍稀释时的pH 纯净水为6.5至8.5。 可以稳定地保持抗坏血酸或其衍生物的含水凝胶具有高凝胶强度，对被粘物表现出良好的粘附性，并且不会提供液体脱水收缩。

公开(公告)号：WO2006112533A1

公开(公告)日：2006-10-26

申请号：PCT/JP2006/308496

申请日：2006-04-18

Applicant: SHOWA DENKO K.K. ,  ISHII, Tetsuya ,  KANAYAMA, Manabu

Inventor： ISHII, Tetsuya ,  KANAYAMA, Manabu

IPC: B01J13/00 ,  A61K9/70 ,  A61K47/32

CPC classification number: B01J13/0056 ,  A61K9/7023 ,  C08J3/075 ,  C08J2333/02

Abstract: Provides a water-containing gel form which exhibits reduced stickiness to the attached material, good sence of use and low irritation to skin, forms no syneresis liquid, has simple composition and is easily prepared. Further, provides a method to adjust arbitrarily crosslinking speed on production of a water-containing gel form using a (meth)acrylic acid-based polymer. (1) a composition for water-containing gel form comprising at least one kind of compound (D) selected from the group consisting of compounds containing a monovalent or divalent metal ion, and a (meth)acrylic acid-based polymer (A), water (C) and a crosslinker (B), which reacts with carboxyl groups, as major components, (2) a water-containing gel form obtained from the composition, (3) a production method of the water-containing gel form and (4) a transdermal formulation, cooling sheet and cosmetics using the water-containing gel form. A production method of a water-containing gel form, wherein crosslinking speed of the (meth)acrylic acid-based polymer is adjusted by adding at least one kind of metal salt (component D') selected from the group consisting of metal salts containing a monovalent or divalent metal ion when the (meth)acrylic acid-based polymer (component A) is crosslinked by mixing with an aluminum-containing compound (component B') and water (component C).

Abstract translation: 提供含水凝胶形式，其对附着材料的粘性降低，使用效果好，对皮肤的刺激性低，不形成脱水液体，组成简单，容易制备。 此外，提供了使用（甲基）丙烯酸系聚合物调制含水凝胶形状的任意交联速度的方法。 （1）包含选自由一价或二价金属离子的化合物和（甲基）丙烯酸类聚合物（A）组成的组中的至少一种化合物（D）的含水凝胶形式的组合物， 水（C）和与羧基反应的交联剂（B）作为主要成分，（2）从组合物获得的含水凝胶形式，（3）含水凝胶形式的制备方法和（ 4）透皮制剂，冷却片和使用含水凝胶形式的化妆品。 含水凝胶形式的制造方法，其中，通过添加至少一种金属盐（成分D'）调整所述（甲基）丙烯酸系聚合物的交联速度，所述金属盐（D'）选自由 当（甲基）丙烯酸系聚合物（A成分）与含铝化合物（B'）和水（C成分）混合而交联时，为一价或二价金属离子。

公开(公告)号：WO2004039358A1

公开(公告)日：2004-05-13

申请号：PCT/JP2003/013836

申请日：2003-10-29

Applicant: SHOWA DENKO K.K. ,  ISHII, Tetsuya

Inventor： ISHII, Tetsuya

IPC: A61K9/70

CPC classification number: A61K9/7061 ,  A61K31/196 ,  A61K31/485 ,  A61K47/32 ,  C08L2666/04 ,  C09J133/04

Abstract: An adhesive composition for dermal patches, comprising (A) a (meth)acrylic acid-base polymer having repeating units represented by formulae (1) and (2): (wherein R 1 and R 2 each independently represents a hydrogen atom or a methyl group and M represents NH 4 + or an alkali metal) with the ratio of (1)/(2) being in a range of 100/0 to 90/10 (by mol), (B) water, (C) a polyhydric alcohol and (D) an aluminum compound, with the content of (B) water being from 5 to 30 mass%; and a production process thereof. The adhesive composition for dermal patch of the present invention can contain a large amount of polyhydric alcohol between skeletons of the adhesive layer and forms a stable between skeletons of the adhesive layer and forms a stable base material free from syneresis of the polyhydric alcohol. Furthermore, the dermal patch using the adhesive composition for dermal patch of the present invention is excellent in the release property and adherence and has high safety.

Abstract translation: 一种用于真皮贴剂的粘合剂组合物，其包含（A）具有由式（1）和（2）表示的重复单元的（甲基）丙烯酸基聚合物：（其中R 1和R 2各自独立地表示氢 原子或甲基，M表示NH 4 +或碱金属），（1）/（2）的比例在100/0〜90/10（摩尔）的范围内，（B）水， （C）多元醇和（D）铝化合物，（B）水的含量为5〜30质量％。 及其制造方法。 本发明的皮肤贴剂用粘合剂组合物可以在粘合剂层的骨架之间含有大量的多元醇，并且在粘合层的骨架之间形成稳定的多孔醇，形成不含多元醇的脱水收缩的稳定的基材。 此外，使用本发明的皮肤贴剂用粘合剂组合物的皮肤贴剂，其剥离性和粘着性优异，安全性高。

公开(公告)号：WO2009018355A1

公开(公告)日：2009-02-05

申请号：PCT/US2008/071614

申请日：2008-07-30

Applicant: AFL TELECOMMUNICATIONS LLC ,  TANAKA, Daiichiro ,  TSUMANUMA, Takashi ,  DUAN, Mingming ,  FOLEY, Sean ,  TORIYA, Tomoaki ,  ISHII, Tetsuya

Inventor： TANAKA, Daiichiro ,  TSUMANUMA, Takashi ,  DUAN, Mingming ,  FOLEY, Sean ,  TORIYA, Tomoaki ,  ISHII, Tetsuya

IPC: G02B6/04

CPC classification number: G02B6/3624 ,  A61B1/0011 ,  A61B1/00165 ,  A61B5/0059 ,  A61B2562/12 ,  G02B6/04 ,  G02B6/2552

Abstract: A method for manufacturing an optical probe which uses optical fibers arranged in parallel which can be easily bent by application of a heat source to improve the performance of the optical probe. The bend may be created by application of heat by a heat source and then forcing a change in the shape of the optical probe. Alternatively, an optical probe may be bent in room temperature and then by applying heat from a heat source, a bend can be created in the optical probe.

Abstract translation: 一种光学探针的制造方法，其使用并联布置的光纤，其可以通过施加热源容易地弯曲，以提高光学探针的性能。 弯曲可以通过由热源施加热而产生，然后迫使光学探头的形状发生变化。 或者，光学探针可以在室温下弯曲，然后通过从热源施加热量，可以在光学探针中产生弯曲。

公开(公告)号：WO2007018279A1

公开(公告)日：2007-02-15

申请号：PCT/JP2006/315894

申请日：2006-08-04

Applicant: SHOWA DENKO K.K. ,  UCHIDA, Hiroshi ,  ISHII, Tetsuya

Inventor： UCHIDA, Hiroshi ,  ISHII, Tetsuya

IPC: C07C231/24 ,  C07C233/05

CPC classification number: C07C231/24 ,  C07C233/05 ,  C08F226/02

Abstract: Disclosed is a process for producing high-purity N-vinylcarboxamides comprising: (A) a step of dissolving a crude N-vinylcarboxamide in an alcohol having 1 to 3 carbon atoms, the crude N-vinylcarboxamide containing 50 to 97% by mass of an N-vinylcarboxamide; (B) a step of adding an aliphatic hydrocarbon having 5 to 10 carbon atoms to the composition obtained in the step (A) to precipitate a crystal of the N-vinylcarboxamide; and (C) a step of separating the crystal of the N-vinylcarboxamide precipitated in the step (B).

Abstract translation: 公开了一种高纯度N-乙烯基甲酰胺的制备方法，其包括：（A）将粗N-乙烯基甲酰胺溶解在具有1〜3个碳原子的醇中的工序，所述粗N-乙烯基甲酰胺含有50〜97质量％ N-乙烯基羧酰胺; （B）向工序（A）得到的组合物中添加碳原子数为5〜10的脂肪族烃的工序，使N-乙烯基甲酰胺的结晶析出; 和（C）分离步骤（B）中析出的N-乙烯基甲酰胺的晶体的步骤。