公开(公告)号：WO2018227018A1

公开(公告)日：2018-12-13

申请号：PCT/US2018/036554

申请日：2018-06-07

Applicant: SILVERBACK THERAPEUTICS, INC.

Inventor： THOMPSON, Peter Armstrong ,  EDRIS, Badreddin ,  COBURN, Craig Alan ,  BAUM, Peter Robert ,  ODEGARD, Valerie

IPC: A61K39/395 ,  A61K47/48 ,  A61K47/50 ,  A61K47/68 ,  C07K16/28

Abstract: Antibody conjugates of immune-modulatory compounds and pharmaceutical compositions for use in the treatment of disease, such as fibrotic diseases, autoimmune, or autoinflammatory diseases, are disclosed herein. The disclosed conjugates are useful, among other things, in treating fibrotic diseases, autoimmune diseases, or autoinflammatory diseases, such as by modulating TGFβR1, TGFβR2, TNKS, TNIK, or mTOR.

公开(公告)号：WO2018227023A1

公开(公告)日：2018-12-13

申请号：PCT/US2018/036560

申请日：2018-06-07

Applicant: SILVERBACK THERAPEUTICS, INC.

Inventor： THOMPSON, Peter Armstrong ,  EDRIS, Badreddin ,  COBURN, Craig Alan ,  BAUM, Peter Robert

IPC: A61K31/4025 ,  C07D207/16 ,  C07D417/12 ,  C07D417/14

Abstract: Various compositions are disclosed. The compositions of composition-immune stimulatory compound conjugates are also provided. Additionally provided are the methods of preparation and uses of the composition-immune stimulatory compound conjugates. This includes methods for treating disorders, such as cancer.