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公开(公告)号：WO2021168274A1
公开(公告)日：2021-08-26
申请号：PCT/US2021/018810
申请日：2021-02-19
摘要： The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates. The present disclosure also provides for anti-Nectin-4 antibodies or antigen binding fragments thereof and method for using the antibodies or antigen binding fragments thereof in treating cancer.
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公开(公告)号：WO2021067644A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053870
申请日：2020-10-01
摘要： Combination therapies using a conjugate comprising a TLR agonist and an antibody that binds a tumor associated antigen or liver cell antigen, and a second therapeutic agent, such as an immune checkpoint inhibitor, are provided for treating cancer or viral infections. Combination therapies using a conjugate comprising a TLR agonist and an antibody that binds HER2, and a second therapeutic agent are also provided for treating cancer.
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公开(公告)号：WO2022006327A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/039974
申请日：2021-06-30
发明人： BAUM, Peter R. , DUBOSE, Robert , ODEGARD, Valerie , TAN, Philip , THOMPSON, Peter A. , SMITH, Sean W. , STEVENS, Brenda
IPC分类号： A61K47/68 , C07K16/28 , A61P1/16 , A61K47/6803 , A61K47/6849 , C07K16/2851 , C07K2317/24 , C07K2317/565
摘要： The disclosure provides conjugates of anti-ASGR1 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating liver viral infections with the conjugates. The disclosure also provides for anti-ASGR1 antibodies or antigen binding fragments thereof and methods for using the antibodies or antigen binding fragments thereof in treating liver viral infections.
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公开(公告)号：WO2021011834A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042430
申请日：2020-07-16
IPC分类号： C07D401/14 , C07D405/14 , C07D471/04 , A61K31/437 , A61K47/68 , A61P35/00
摘要： ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
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公开(公告)号：WO2020056198A3
公开(公告)日：2020-03-19
申请号：PCT/US2019/050900
申请日：2019-09-12
IPC分类号： C07D403/10 , A61K31/55 , A61P35/00 , A61P37/00
摘要： Benzazepine compounds and salts thereof, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds and salts thereof are useful, among other things, in treating of cancer and activating an immune response. Additionally, benzazepine compounds or salts thereof attached to an antibody construct to form an antibody conjugate are described herein.
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公开(公告)号：WO2018144955A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/016757
申请日：2018-02-02
摘要： Construct-peptide compositions are disclosed. Construct-peptide compositions conjugated to immune stimulatory compounds are also provided. Additionally provided are the methods of preparation and use of the construct-peptide compositions and construct-peptide compositions conjugated to immune stimulatory compound. This includes methods for treating disorders, such as cancer.
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公开(公告)号：WO2022076905A1
公开(公告)日：2022-04-14
申请号：PCT/US2021/054296
申请日：2021-10-08
发明人： SMITH, Sean Wesley , HUNT, Kevin W.
IPC分类号： C07D487/04 , C07D401/14 , A61K31/498 , A61K31/4709 , A61K31/4439 , A61K31/444 , A61K47/54 , A61K47/68 , A61P35/00
摘要： ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein. The disclosed compounds and conjugates are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5.
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公开(公告)号：WO2021102332A1
公开(公告)日：2021-05-27
申请号：PCT/US2020/061618
申请日：2020-11-20
发明人： TAN, Philip , STEVENS, Brenda , SMITH, Sean Wesley
摘要： Conjugates comprising a TGFβR2 inhibitor and an anti-LRRC15 antibody, compositions comprising the conjugates, and use of the conjugates in the treatment of disease, such as fibrosis and cancer, are disclosed herein. Also disclosed herein are anti-LRRC15 antibodies, including humanized anti-LRRC15 antibodies.
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公开(公告)号：WO2020056194A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/050896
申请日：2019-09-12
IPC分类号： C07D401/12 , A61K31/55 , A61P35/00
摘要： Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.
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公开(公告)号：WO2018227023A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036560
申请日：2018-06-07
IPC分类号： A61K31/4025 , C07D207/16 , C07D417/12 , C07D417/14
摘要： Various compositions are disclosed. The compositions of composition-immune stimulatory compound conjugates are also provided. Additionally provided are the methods of preparation and uses of the composition-immune stimulatory compound conjugates. This includes methods for treating disorders, such as cancer.
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