公开(公告)号：WO2015100113A2

公开(公告)日：2015-07-02

申请号：PCT/US2014070970

申请日：2014-12-17

Applicant: SLOAN KETTERING INST CANCER

Inventor： ROTHMAN JEFFREY K ,  SCHWARTZ GARY K

IPC: A61K48/00

CPC classification number: C12N15/1135 ,  A61K38/00 ,  C07K14/003 ,  C12N2310/3181 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5748 ,  G01N2500/10

Abstract: The present invention provides compositions and methods for treating cancer with peptide nucleic acid agents. In some embodiments, the present invention provides methods and compositions relating to peptide nucleic acid agents that target oncogenes. For example, the present invention provides compositions, including pharmaceutical compositions, comprising agents specific for BRAF V600E inhibition, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using BRAF V600E specific peptide nucleic acid agents and/or compositions.

Abstract translation: 本发明提供了用肽核酸剂治疗癌症的组合物和方法。 在一些实施方案中，本发明提供涉及靶向致癌基因的肽核酸试剂的方法和组合物。 例如，本发明提供包含药物组合物的组合物，其包含对BRAF V600E抑制特异的试剂或其片段或特征部分。 本发明还提供了使用BRAF V600E特异性肽核酸试剂和/或组合物的各种治疗和/或诊断方法。

公开(公告)号：WO2004040259A3

公开(公告)日：2004-07-22

申请号：PCT/US0333616

申请日：2003-10-24

Applicant: SLOAN KETTERING INST CANCER ,  SCHWARTZ GARY K

Inventor： SCHWARTZ GARY K

IPC: C12Q1/00 ,  G01N33/50 ,  A61K35/12 ,  A61K39/00 ,  C12Q1/02 ,  C12Q1/34 ,  G01N33/574

CPC classification number: G01N33/5038 ,  G01N33/5011

Abstract: This invention provides a method for screening and quantitating a mixture of compounds for activity comprising steps of contacting the mixture with a system which mimics an organ capable of metabolizing the mixture in an appropriate time to generate a metabolite; and determining the activity of the generated metabolite. This invention also provides a method for identifying an active metabolite from a mixture of compounds comprising steps of contacting the mixture with a system which mimics an organ capable of metabolizing the mixture in an appropriate time to generate a metabolite; and determining the activity of the metabolite generated. Finally, This invention provides various uses of this method and the identified metabolite. Figure (1) shows Huanglian Root (Rhizoma Coopits Chinesis).

Abstract translation: 本发明提供了用于筛选和定量化合物用于活性的混合物的方法，包括以下步骤：使混合物与在合适的时间内能够代谢混合物的器官模拟生成代谢物的系统接触; 并确定产生的代谢物的活性。 本发明还提供了一种用于从化合物混合物中鉴定活性代谢物的方法，包括以下步骤：使混合物与在适当时间内能够代谢混合物的器官模拟生成代谢物的系统接触; 并确定生成的代谢物的活性。 最后，本发明提供了该方法和鉴定的代谢物的各种用途。 图（1）显示黄连根（Rhizoma Coopits Chinesis）。