公开(公告)号：WO2022067043A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/051963

申请日：2021-09-24

Applicant: SOUTHERN METHODIST UNIVERSITY

Inventor： RUNCHEVSKI, Tomche ,  PEKAR, Kyle, B. ,  LEFTON, Jonathan, B.

IPC: A23L33/17 ,  A23L33/175 ,  A61P3/02 ,  C07C279/14

Abstract: The present invention includes a co-crystal of creatine and citric acid obtained by milling, methods of making the same that include a process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising: mixing creatine and citric acid; milling the creatine and citric acid for a time sufficient to form a co-amorphous solid, which co-amorphous solid can be converted into a co-crystal, and nutritional supplements that include the same.