公开(公告)号：WO2010019911A3

公开(公告)日：2010-02-18

申请号：PCT/US2009/053932

申请日：2009-08-14

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SOUTHERN METHODIST UNIVERSITY ,  D'MELLO, Santosh, R. ,  BIEHL, Edward, A.

Inventor： D'MELLO, Santosh, R. ,  BIEHL, Edward, A.

IPC: C07D241/40 ,  C07D319/18 ,  C07D335/04 ,  C07D265/36 ,  C07D279/16 ,  A61K31/535 ,  A61P21/00

Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.

公开(公告)号：WO2006050281A2

公开(公告)日：2006-05-11

申请号：PCT/US2005/039302

申请日：2005-10-28

Applicant: SOUTHERN METHODIST UNIVERSITY ,  LEE, Choon Sae

Inventor： LEE, Choon Sae

IPC: H01Q1/38

CPC classification number: H01Q9/0471

Abstract: A wireless communication device includes an antenna (600g) configured with two conductive elements (601/602) separated by an insulating medium (603). One conductive element (602) is a ground plane and the other is a microstrip line (601). The ground plane (602) is formed with a bend (644) proximate an end. The microstrip line and the ground plane exhibit a characteristic impedance that may vary along the length of the microstrip line. The separation distance of the microstrip line (601) from the ground plane (602) is changed to reduce the resonant frequency of the microstrip line.

Abstract translation: 无线通信装置包括配置有由绝缘介质（603）分离的两个导电元件（601/602）的天线（600g）。 一个导电元件（602）是接地平面，另一个是微带线（601）。 接地平面（602）形成有靠近端部的弯曲部（644）。 微带线和接地平面呈现出沿着微带线的长度可能变化的特征阻抗。 改变微带线（601）与接地层（602）的间隔距离，以减小微带线的谐振频率。

公开(公告)号：WO2020033975A1

公开(公告)日：2020-02-13

申请号：PCT/US2019/046233

申请日：2019-08-12

Applicant: SOUTHERN METHODIST UNIVERSITY ,  RETINA FOUNDATION OF THE SOUTHWEST

Inventor： CLARK, Corey ,  CSAKY, Karl

IPC: G06F19/00

Abstract: Methods, systems, and computer readable media for analyzing an image using machine learning and human computation. A method for analyzing an image includes providing, via multiple instances of an interactive application (334) for analysis of the image, multiple instances, respectively, of the image and receiving, via the interactive application, data (240) from results of analyses of the image including multiple sets of user inputs from the analyses of the multiple instances of the image, respectively. The multiple sets of user inputs are from multiple users, respectively and the multiple users are associated with the multiple instances of the interactive application, respectively. The method further includes processing the received data to identify areas of interest within the image based on the multiple sets of user inputs and analyzing the image using a machine learning algorithm (245) to identify structures in the image based on the identified areas of interest within the image.

公开(公告)号：WO2007094885A3

公开(公告)日：2007-08-23

申请号：PCT/US2006/061750

申请日：2006-12-07

Applicant: SOUTHERN METHODIST UNIVERSITY ,  ZHU, Dunming ,  HUA, Ling ,  BIEHL, Edward ,  MUKHERJEE, Chandrani

Inventor： ZHU, Dunming ,  HUA, Ling ,  BIEHL, Edward ,  MUKHERJEE, Chandrani

IPC: C12N9/78 ,  C12P7/42 ,  C12P13/00

Abstract: The present disclosure relates to methods of rational genome mining. A method may include narrowing the number of clones that would otherwise need to be screened and/or identifying a gene with a desired catalytic activity. The disclosure also relates to a nitrile hydrolase from Bradyrhizobium japonicum USDA110 first identified by rational genome mining. In addition, the disclosure relates to nitrilase bll6402 and catalytically active variants capable of converting an α-hydroxy nitriles, a β-hydroxy nitrile and/or an α, ω-dinitrile to a carboxylic acid.

公开(公告)号：WO2003015214A1

公开(公告)日：2003-02-20

申请号：PCT/US2002/021839

申请日：2002-08-09

Applicant: SOUTHERN METHODIST UNIVERSITY ,  LEE, Choon, Sae

Inventor： LEE, Choon, Sae

IPC: H01Q9/28

CPC classification number: H01Q21/065 ,  H01Q9/0407 ,  H01Q21/0006

Abstract: An apparatus and method to reduce the size of a microstrip antenna (900) without sacrificing antenna efficiency too much are described. The antenna structure includes discontinuity of strip width in the middle of the antenna patch (902) to reduce the size of the antenna at a given resonant frequency. The antenna structure further includes a plurality of patches of different widths connected to each other at junctions (912). The junctions (912) are placed symmetrically to ensure maximum radiation at the boresight and also to further reduce cross-polarization levels. A coaxial feed (906) is connected at a predetermined location near the center of a patch, having a narrower width, in order to match the input impedance of the antenna to the coaxial feed (906).

Abstract translation: 描述了在不牺牲天线效率的情况下减小微带天线（900）的尺寸的装置和方法。 天线结构包括在天线贴片（902）的中间的条带宽度的不连续性，以在给定的谐振频率下减小天线的尺寸。 天线结构还包括在连接处（912）处彼此连接的不同宽度的多个贴片。 接头（912）对称放置，以确保视轴处的最大辐射，并进一步降低交叉极化水平。 同轴馈电（906）连接在具有较窄宽度的贴片中心附近的预定位置，以便将天线的输入阻抗与同轴馈电（906）匹配。

公开(公告)号：WO1996024165A1

公开(公告)日：1996-08-08

申请号：PCT/US1995016399

申请日：1995-12-29

Applicant: SOUTHERN METHODIST UNIVERSITY

Inventor： SOUTHERN METHODIST UNIVERSITY ,  BUTLER, Donald, P. ,  CELIK-BUTLER, Zeynep ,  PAO-CHUAN, Shan

IPC: H01L29/12

CPC classification number: H01L31/032 ,  G01J5/20 ,  G01J5/34 ,  H01L27/16 ,  H01L31/095

Abstract: A thermal detector (B) includes a transducer layer (2) of semiconducting yttrium barium copper oxide which is sensitive at room temperature to radiation and provides detection of infrared radiation. In a gate-insulated transistor embodiment, a layer of ferroelectric semiconducting yttrium barium copper oxide (34) forms a gate insulator layer and increases capacitance of the transistor or latches of the transistor according to the polarization direction of the ferroelectric layer.

Abstract translation: 热检测器（B）包括半导体钇钡铜氧化物的换能器层（2），其在室温下对辐射敏感并提供红外辐射的检测。 在栅极绝缘晶体管的实施例中，铁电半导体钇钡铜氧化物层34形成栅极绝缘体层，并根据铁电层的极化方向增加晶体管的晶体管或锁存器的电容。

公开(公告)号：WO2005114792A1

公开(公告)日：2005-12-01

申请号：PCT/US2004/011934

申请日：2004-04-19

Applicant: SOUTHERN METHODIST UNIVERSITY ,  LEE, Choon, Sae

Inventor： LEE, Choon, Sae

IPC: H01Q21/06

CPC classification number: H01Q21/0075 ,  H01Q1/38 ,  H01Q21/0006 ,  H01Q21/065

Abstract: A microstrip antenna has a single dielectric layer with a conductive ground plane disposed on one side, and an array of spaced apart radiating patches disposed on the other side of the dielectric layer. The radiating patches are interconnected with a feed terminal via stripline elements. Responsive to electromagnetic energy, a high-order standing wave is induced in the antenna and a directed beam is transmitted from and/or received into the antenna. A dual­-mode embodiment is configured such that standing wave nodes occur at the intersection of orthogonally situated striplines to minimize cross-polarization levels of the signals and the cross-talk between the two modes of operation.

Abstract translation: 微带天线具有设置在一侧上的导电接地面的单个介电层和设置在电介质层另一侧上的间隔开的散射片的阵列。 辐射贴片通过带状线元件与馈电端子互连。 响应于电磁能量，在天线中引起高阶驻波，并且有源波束从天线发射和/或接收到天线中。 双模实施例被配置为使得驻波节点出现在正交位置的带状线的交叉处，以使信号的交叉极化水平和两种操作模式之间的串扰最小化。

公开(公告)号：WO2022067043A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/051963

申请日：2021-09-24

Applicant: SOUTHERN METHODIST UNIVERSITY

Inventor： RUNCHEVSKI, Tomche ,  PEKAR, Kyle, B. ,  LEFTON, Jonathan, B.

IPC: A23L33/17 ,  A23L33/175 ,  A61P3/02 ,  C07C279/14

Abstract: The present invention includes a co-crystal of creatine and citric acid obtained by milling, methods of making the same that include a process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising: mixing creatine and citric acid; milling the creatine and citric acid for a time sufficient to form a co-amorphous solid, which co-amorphous solid can be converted into a co-crystal, and nutritional supplements that include the same.

公开(公告)号：WO2020243670A1

公开(公告)日：2020-12-03

申请号：PCT/US2020/035455

申请日：2020-05-30

Applicant: MICHIGAN AEROSPACE CORPORATION ,  SOUTHERN METHODIST UNIVERSITY

Inventor： TCHORYK, Peter ,  FOURGUETTE, Dominique ,  OTUGEN, Volkan

IPC: G02B6/26 ,  G01B9/02 ,  G01B11/14 ,  G01P3/36 ,  G01V1/28

Abstract: This device allows one to measure seismic activity from a hand-held device, in particular a mobile phone. A microfabricated whispering gallery mode (WGM) based seismometer operates in conjunction with an application installed on a mobile phone. By converting the sensor output from the seismometer, a measurement is performed by the application with a simple cross- correlation operation that requires low processing power.

公开(公告)号：WO2006026524A2

公开(公告)日：2006-03-09

申请号：PCT/US2005/030590

申请日：2005-08-26

Applicant: SOUTHERN METHODIST UNIVERSITY ,  HARROD, Robert

Inventor： HARROD, Robert

IPC: A61K48/00 ,  A61K38/16 ,  A61K31/551

CPC classification number: C12N9/90 ,  A61K31/522 ,  A61K31/551 ,  A61K38/52 ,  A61K48/00 ,  C07K14/005 ,  C12N2510/04 ,  C12N2740/16322 ,  C12Q1/6897 ,  C12Q1/703 ,  G01N33/5008 ,  G01N2333/163 ,  G01N2333/91245 ,  G01N2333/99 ,  C12Q2521/531

Abstract: Werner's Syndrome helicase (WRN) interacts in Tat/TAR-RNA chromatin-remodeling complexes assembled on the HIV-1 LTR to promote transcriptional activation and viral replication. WRN markedly increases basal HIV-1 transcription and synergizes with Tat to support LTR trans-activation. Inhibition of WRN functions, through expression of the trans-dominant-negative WRNK577M mutant, potently represses HIV-1 LTR trans-activation and prevents intracellular synthesis of p24Gag and inhibits virus production in HIV-infected H9HIV-1IIIB lymphocytes. Therefore, the present disclosure provides a novel target for anti-HIV therapy. Methods and compositions of the disclosure may be used to perform high throughput screens for small molecule anti-HIV therapeutics. Such therapeutics may inhibit a stage in the HIV replicative cycle not affected by current anti-HIV drugs.

Abstract translation: 维纳综合征解旋酶（WRN）与组装在HIV-1 LTR上的Tat / TAR-RNA染色质重塑复合物相互作用，以促进转录激活和病毒复制。 WRN显着增加基本的HIV-1转录，并与Tat协同作用以支持LTR反式激活。 通过反式显性阴性WRNK577M突变体的表达抑制WRN功能有效抑制HIV-1 LTR反式激活，并阻止p24Gag的细胞内合成并抑制HIV感染的H9HIV-1IIIB淋巴细胞中的病毒产生。 因此，本公开提供了抗HIV治疗的新靶标。 本公开的方法和组合物可用于对小分子抗HIV治疗剂进行高通量筛选。 这种治疗剂可能会抑制HIV复制循环中不受现有抗HIV药物影响的阶段。