公开(公告)号：WO2014145205A2

公开(公告)日：2014-09-18

申请号：PCT/US2014/029927

申请日：2014-03-15

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： ZUO, Jian ,  CHEN, Taosheng ,  WALTERS, Brandon ,  KUO, Bryan ,  WALTERS, Bradley

IPC: A61K31/519

CPC classification number: A61K38/1703 ,  A61K9/0046 ,  A61K31/05 ,  A61K31/222 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/55 ,  A61K35/12 ,  A61K38/17 ,  A61K45/06 ,  C12N5/0602 ,  C12N5/062

Abstract: In one aspect, the invention relates to pharmaceutical compositions comprising agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof; and agents that inhibit the expression of p27 Kipl , or pharmaceutically acceptable salts, solvates, or polymorphs thereof, which are useful for inducing the formation of cochlear hair cells; and methods of treating hearing impairments or disorders using the compositions. In one aspect, the invention relates to pharmaceutical compositions comprising β-catenin; and agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract translation: 一方面，本发明涉及包含活化Atoh1表达的试剂或其药学上可接受的盐，溶剂化物或多晶型物的药物组合物; 以及可用于诱导耳蜗毛细胞形成的p27Kipl或其药学上可接受的盐，溶剂化物或多晶型物的表达的药剂; 以及使用该组合物治疗听力障碍或障碍的方法。 一方面，本发明涉及包含β-联蛋白的药物组合物; 以及激活Atoh1表达的药剂，或其药学上可接受的盐，溶剂化物或多晶型物。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。