公开(公告)号：WO2016019311A1

公开(公告)日：2016-02-04

申请号：PCT/US2015/043240

申请日：2015-07-31

Applicant: STC.UNM ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： SALAMEH, Ahmed ,  LEE, Alessandro ,  NUNES, Diana, N. ,  DIAD-NETO, Emmanuel ,  PASQUALINE, Renata ,  ARAP, Wadih

IPC: A61K31/7088

CPC classification number: A61K31/7088

Abstract: Methods for detecting and treating prostate cancers are provided. In some aspects, methods for detecting a prostate cancer comprise measuring a level of PRUNE2 expression and/or PCA3 expression in a sample from a subject. In further aspects, a method for treating prostate cancer is provided comprising administering a PRUNE2 tumor suppressor polypeptide or a nucleic acid molecule that inhibits expression of PC A3 RNA.

Abstract translation: 提供了检测和治疗前列腺癌的方法。 在一些方面，用于检测前列腺癌的方法包括测量来自受试者的样品中PRUNE2表达和/或PCA3表达的水平。 在另外的方面，提供了一种治疗前列腺癌的方法，包括施用PRUNE2肿瘤抑制多肽或抑制PC A3 RNA表达的核酸分子。