公开(公告)号：WO2019226050A3

公开(公告)日：2019-11-28

申请号：PCT/NL2019/050300

申请日：2019-05-23

Applicant: WAGENINGEN UNIVERSITEIT ,  STICHTING WAGENINGEN RESEARCH

Inventor： DE WOLF, Frederik Anton ,  VAN AMERONGEN, Aart ,  SAVELKOUL, Hubertus Franciscus Jozef

IPC: A61K39/12 ,  A61P31/16

Abstract: The invention relates to a protein comprising at least one immune stimulating domain, at least one hydrophilic random coil domain, and at least one Virus Entry inhibitor (VEI) domain. The invention further relates to a nucleic acid molecule encoding said protein, to an expression construct comprising said nucleic acid molecule, to a pharmaceutical composition comprising the protein, and to methods of producing the protein.

公开(公告)号：WO2019226050A2

公开(公告)日：2019-11-28

申请号：PCT/NL2019/050300

申请日：2019-05-23

Applicant: WAGENINGEN UNIVERSITEIT ,  STICHTING WAGENINGEN RESEARCH

Inventor： DE WOLF, Frederik Anton ,  VAN AMERONGEN, Aart ,  SAVELKOUL, Hubertus Franciscus Jozef

IPC: A61K39/12 ,  A61P31/16

Abstract: The invention relates to a protein comprising at least one immune stimulating domain, at least one hydrophilic random coil domain, and at least one Virus Entry inhibitor (VEI) domain. The invention further relates to a nucleic acid molecule encoding said protein, to an expression construct comprising said nucleic acid molecule, to a pharmaceutical composition comprising the protein, and to methods of producing the protein.

公开(公告)号：WO2017137306A1

公开(公告)日：2017-08-17

申请号：PCT/EP2017/052278

申请日：2017-02-02

Applicant: STICHTING WAGENINGEN RESEARCH

Inventor： VAN AMERONGEN, Aart

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/089 ,  B01L2400/086

Abstract: Disclosed is a microfluidic device for detecting the presence and/or amount of analytes in a fluid comprising a first and a second element both comprising a hydrophobic surface. Both hydrophobic surfaces comprise a hydrophilic pathway, wherein the hydrophilic pathways are configured in a mirror image of each other in such a way that when the first and second elements are placed upon each other with the hydrophilic pathways facing each other a capillary fluid channel on the hydrophobic surfaces of the elements is formed, and wherein at least one of the hydrophilic pathways comprises a sensing region comprising capture means.

Abstract translation: 公开了一种用于检测流体中分析物的存在和/或量的微流体装置，所述流体包含均包含疏水性表面的第一和第二元素。 两个疏水表面均包含亲水性路径，其中亲水性路径以彼此镜像成像的方式配置成使得当第一和第二元件彼此放置时亲水性路径彼此面对，第二和第二元件上的毛细管流体通道 形成元件的疏水表面，并且其中至少一个亲水路径包含含有捕获装置的感测区域。