公开(公告)号：WO2010135655A2

公开(公告)日：2010-11-25

申请号：PCT/US2010/035789

申请日：2010-05-21

申请人： STRATATECH CORPORATION ,  COMER, Allen R. ,  ALLEN-HOFFMANN, B. Lynn

发明人： COMER, Allen R. ,  ALLEN-HOFFMANN, B. Lynn

IPC分类号： C12N15/63 ,  C12N5/04 ,  C07K14/54 ,  A61K38/20 ,  A61P17/00

CPC分类号： A61K38/208 ,  A61K35/12 ,  A61K48/00 ,  C07K14/5434 ,  C12N5/0629 ,  C12N2501/23 ,  C12N2510/00

摘要： The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.

摘要翻译： 本发明一般涉及用于治疗患有皮肤癌或最近除去皮肤癌的患者的组合物。 更具体地，本发明提供了工程化以表达外源IL-12的人皮肤代用品，以及用于制备人工皮肤代用品以表达外源性IL-12的组合物和方法。 此外，本发明提供了治疗患者皮肤癌已被去除的部位的方法，人类皮肤替代物被工程化以表达外源IL-12。

公开(公告)号：WO2022261248A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/032726

申请日：2022-06-08

申请人： STRATATECH CORPORATION

发明人： COMER, Allen R. ,  GRATZ, Kenneth R. ,  ALLEN-HOFFMANN, B. Lynn

IPC分类号： A61K35/36 ,  A61K35/33 ,  A61L27/54

摘要： The present disclosure is directed to viable bioengineered allogeneic cellularized construct.

公开(公告)号：WO2021062359A1

公开(公告)日：2021-04-01

申请号：PCT/US2020/053061

申请日：2020-09-28

申请人： STRATATECH CORPORATION

发明人： SMIELL, Janice ,  COMER, Allen ,  LOKUTA, Mary ,  ALLEN-HOFFMANN, B. Lynn

IPC分类号： A61F2/10 ,  A61K35/12 ,  A61K35/36 ,  A61K48/00 ,  A61L27/60 ,  A61P17/02

摘要： The present disclosure provides methods for treating acute wounds and improving outcomes by applying to an acute wound a skin substitute that is an organotypic human skin equivalent comprising NIKS cells. In certain embodiments, the closed wound has improved vascularity, improved pigmentation, decreased thickness, decreased pain, increased pliability, increased surface area, decreased stiffness, decreased itching, improved color, or any combination thereof, as assessed by an observer or by the subject, as compared to an autograft or another skin substitute.

公开(公告)号：WO2022011141A1

公开(公告)日：2022-01-13

申请号：PCT/US2021/040892

申请日：2021-07-08

申请人： STRATATECH CORPORATION

发明人： COMER, Allen R. ,  SMIELL, Janice ,  RUTAN, Randi ,  LOKUTA, Mary ,  ALLEN-HOFFMANN, B. Lynn

IPC分类号： A61L27/60 ,  A61K35/36 ,  A61L27/54 ,  A61P17/02 ,  A61K35/12 ,  A61P31/00

摘要： The present disclosure provides methods for treating wounds by applying a meshed autograft and skin substitute overlay wherein the skin substitute is an organotypic human skin equivalent comprising NIKS® cells.

公开(公告)号：WO2014160000A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/025599

申请日：2014-03-13

申请人： STRATATECH CORPORATION

发明人： ALLEN-HOFFMANN, B. Lynn ,  PIRNSTILL, John C. ,  GRATZ, Kenneth R. ,  COMER, Allen R.

IPC分类号： A61F2/10 ,  A61F2/00

CPC分类号： A01N1/0221

摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.

摘要翻译： 本发明一般涉及用于制备，储存，运输和使用由器官培养形成的皮肤等同物的系统和方法。 特别地，本发明涉及用于冷冻保存活的皮肤代用品的系统和方法。