公开(公告)号：WO2016174082A1

公开(公告)日：2016-11-03

申请号：PCT/EP2016/059398

申请日：2016-04-27

申请人： SWEDISH ORPHAN BIOVITRUM AB (PUBL)

发明人： FLORIN-ROBERTSSON, Ebba ,  FRANSSON, Jonas ,  MOORE, Barry D.

IPC分类号： A61K9/00 ,  A61K38/20 ,  A61P27/02

CPC分类号： A61K38/2006 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61P27/02 ,  A61P27/04 ,  A61P27/14 ,  A61K2300/00

摘要： The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the present invention relates to use of said compositions for treatment of for example ophthalmic disorders.

摘要翻译： 本发明涉及包含阿那镍，缓冲剂和任选的至少一种渗透剂和任选的其它赋形剂的组合物。 此外，本发明涉及所述组合物用于治疗眼科疾病的用途。

公开(公告)号：WO2012108828A1

公开(公告)日：2012-08-16

申请号：PCT/SE2012/050124

申请日：2012-02-09

申请人： SWEDISH ORPHAN BIOVITRUM AB (publ) ,  FRANSSON, Jonas ,  FLORIN-ROBERTSSON, Ebba

发明人： FRANSSON, Jonas ,  FLORIN-ROBERTSSON, Ebba

IPC分类号： A61K38/20 ,  A61K9/08 ,  A61P29/00

CPC分类号： A61K38/2006 ,  A61K9/0019 ,  A61K9/10 ,  A61K38/00 ,  A61K38/1793 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  C07K14/545 ,  C07K14/7155

摘要： The present invention relates to pharmaceutical compositions comprising anakinra as an active compound in the absence of sodium citrate. The said pharmaceutical compositions are useful for the treatment of IL-1 mediated disorders and for decreasing nociceptive pain during such treatment.

摘要翻译： 本发明涉及在不存在柠檬酸钠的情况下包含阿达辛拉作为活性化合物的药物组合物。 所述药物组合物可用于治疗IL-1介导的病症和在这种治疗期间降低伤害性疼痛。

公开(公告)号：WO2019097003A1

公开(公告)日：2019-05-23

申请号：PCT/EP2018/081588

申请日：2018-11-16

申请人： SWEDISH ORPHAN BIOVITRUM AB (PUBL)

发明人： FRANSSON, Jonas

IPC分类号： A61M5/19 ,  A61K9/00 ,  A61J1/20 ,  A61M5/32 ,  A61M5/31

CPC分类号： A61M5/19 ,  A61J1/2093 ,  A61K9/0019 ,  A61M5/329 ,  A61M2005/3128

摘要： A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.

公开(公告)号：WO2015158707A1

公开(公告)日：2015-10-22

申请号：PCT/EP2015/058063

申请日：2015-04-14

申请人： SWEDISH ORPHAN BIOVITRUM AB (PUBL)

发明人： FRANSSON, Jonas ,  HIMBERT, Hans ,  REINIUS, Pelle

IPC分类号： A61M5/31 ,  A61M5/315

CPC分类号： A61M5/3148 ,  A61M5/3129 ,  A61M5/3137 ,  A61M5/315 ,  A61M5/31595 ,  A61M2005/3139 ,  A61M2207/00

摘要： The present invention relates to a syringe (100) having a barrel (2), a plunger arranged to travel within said barrel (2) and a plunger rod (1) for driving the plunger in a bidirectional manner. The plunger rod (1) is provided with a head (8) at a distal end thereof and a plurality of protruding finger grip enhancing means (5) axially spaced along a length of the plunger rod (1).

摘要翻译： 本发明涉及一种具有镜筒（2）的针筒（100），设置成在所述镜筒（2）内行进的柱塞）和用于以双向方式驱动柱塞的柱塞杆（1）。 柱塞杆（1）在其远端处设置有头部（8）和沿着柱塞杆（1）的长度轴向间隔开的多个突出的手指抓握增强装置（5）。