摘要:
A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.
摘要:
The invention refers to a device (100, 500, 510), for example a cartridge, a syringe or an autoinjector, which reduces the possibility of user error and provides an easy and automatic operation during mixing and/or reconstitution, comprising: - a first chamber (105, 505) within the housing, wherein the first chamber (105, 505) contains a first material, - a second chamber (109, 509) comprising a first piston (112, 512) and a second piston (111, 511), wherein the first piston (112, 512) and the second piston (111, 511) are axially moveable within the second chamber (109, 509), and - a second fluid material initially contained within the second chamber (109, 509) between the first piston (112, 512) and the second piston (111, 511 ), wherein the device is adapted such that activation of the device (100, 500, 510) causes movement one of the first piston (112, 512) and the second piston (111, 511 ) in an axial direction of the device thereby - moving the other one of the first piston (112, 512) and the second piston (111, 511 ) into the same axial direction of the device, - opening a fluid communication path between the second chamber (109, 509) and the first chamber (105, 505) and - expelling the second material from the second chamber (109, 509) into the first chamber (105, 505) via the fluid communication path. The invention is further directed to a respective mixing and/or reconstitution method.
摘要:
An apparatus for mixing a fluid material and a solid material comprises (a) a barrel; (b) a plunger displaceable within the barrel; (c) a slider disposed within the barrel between the fluid and solid materials. The slider, when reciprocatively displaced within the barrel, is permeable by the fluid material and the solved solid material under a pressure differential between the fluid and solid materials. The pressure differential is multiply exerted to the slider by the plunger such that a homogeneous mixture is obtained.
摘要:
The present invention relates to oral liquid compositions of guanfacine. The liquid compositions can be immediate release or extended release compositions. The compositions comprise guanfacine in a concentration from about 0.1 mg/mL, to about 12.0 mg/mL of the composition. The liquid compositions can be in the form of ready-to use liquid compositions or reconstituted liquid compositions. It further relates to processes for the preparation of said oral liquid compositions.
摘要:
This invention relates to a discharge spout assembly for a container and a container incorporating such a discharge spout. More specifically, the invention relates to a discharge spout assembly for a pouch-like container having first and second mixable substances contained therein separately from one another until time of use. The discharge spout assembly includes a pair of supporting arms, spaced from one another across a passageway through which a flowable substance is operatively capable of flowing through, and locatable within the container. The periphery of each of the support arms is curved thereby to support the container across the support arms in a manner that alleviates the container from folding on itself and pinching shut flow of the flowable substance to a discharge spout assembly.
摘要:
The proposed design relates to baby feeding vessels. A formula-mixing bottle comprises a first container with a bottom, a second container with a bottom formed by the closure member of a valve, and a cap. The bottom of the second container is formed by a closure member in the form of a raisable disk of a disk valve. The closure member of the raisable valve is in the form of a disk having a screw shaft disposed on one side thereof, and the inside surface of the second container has a seal disposed thereon which forms a seat for the disk of the closure member. The screw shaft is provided with a guide groove and is disposed inside a retaining sleeve which has an arrester mounted in the opening thereof such as to be capable of interacting with the guide groove, said arrester restricting rotation of the screw shaft of the disk of the closure member. The proposed bottle has a simplified structure as a result of the use of elements having a less complex form.
摘要:
The present invention relates to a container unit for engaging with a second container by quickly one-stop plugging-in or coupling to another container, for combining the volume of both containers, wherein each container may separately store a component of a formulation for mixing in a gentle shaking or swirling manner prior to use. The container unit is suitable for coupling in a scalable manner to variety of containers, thereby acting as a universal container system that can be assembled easily into different compartment containers with different opening sizes.
摘要:
A removable container for powder or liquid includes a housing, a spilling mechanism and a bypass element. The housing hangs within a bottle and is capable of storing powder within the bottle while being sealed from a precursor liquid held within the bottle. The spilling mechanism enables the powder to spill out of the housing and into the precursor liquid and the bypass element provides the precursor liquid out of the bottle without mixing with the stored powder.
摘要:
Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.
摘要:
The present invention relates to an aqueous ibuprofen and paracetamol composition of pH 6.3-7.3and to its use. The present invention relates to a method for preparing a combination product of ibuprofen and paracetamol. It also relates to the compositions for use as a medicament, especially for the treatment of pain and/or inflammation;especially for administration of the composition by intravenous injection.