公开(公告)号：WO1997022708A1

公开(公告)日：1997-06-26

申请号：PCT/US1996020716

申请日：1996-12-19

Applicant: SYSTEMIX, INC.

Inventor： SYSTEMIX, INC. ,  PEAULT, Bruno

IPC: C12N15/85

CPC classification number: C07K14/475 ,  A61K2035/124 ,  C12N5/0647 ,  C12N2502/1394

Abstract: The invention provides novel cluster-forming stem cells and stem cell growth factor isolated therefrom.

Abstract translation: 本发明提供了从其分离的新型簇形成干细胞和干细胞生长因子。

公开(公告)号：WO1991016451A1

公开(公告)日：1991-10-31

申请号：PCT/US1991002373

申请日：1991-04-05

Applicant: SYSTEMIX, INC.

Inventor： SYSTEMIX, INC. ,  PEAULT, Bruno

IPC: C12Q01/04

CPC classification number: G01N33/56977

Abstract: Methodology is provided for identifying the presence of human T-lymphocyte progenitor cells. Human thymus tissue is depleted of endogenous lymphoid cells, repopulated with a human cellular composition which is HLA mismatched with the thymus tissue and implanted into a vascularizable site in an immunocompromised host. After at least about two weeks, the tissue may be assayed for the presence of the HLA mismatched T-lymphocytes as indicative of human T-lymphocyte progenitors in this cellular composition.

公开(公告)号：WO1995003693A1

公开(公告)日：1995-02-09

申请号：PCT/US1994008574

申请日：1994-07-29

Applicant: SYSTEMIX, INC.

Inventor： SYSTEMIX, INC. ,  PEAULT, Bruno ,  UCHIDA, Nobuko

IPC: A01N01/02

CPC classification number: C12N5/0647 ,  C12N2501/2306 ,  C12N2501/235 ,  C12N2502/1394

Abstract: A method for obtaining human hematopoietic stem cells is provided by separation of the stem cells from dedicated cells by virtue of a novel stem cell marker. The cells obtained are provided. The isolated cells demonstrate increased proliferative potential.

Abstract translation: 通过新型干细胞标记物将干细胞从专用细胞中分离出来，获得人造血干细胞的方法。 提供获得的细胞。 分离的细胞表现出增加的增殖潜力。

公开(公告)号：WO1993002687A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006309

申请日：1992-07-30

Applicant: SYSTEMIX, INC.

Inventor： SYSTEMIX, INC. ,  PEAULT, Bruno

IPC: A61K35/00

CPC classification number: A01K67/0271

Abstract: Primordial tissue is introduced into immunodeficient hosts, where the primordial tissue develops and differentiates. The chimeric host allows for investigation of the processes and development of the xenogeneic tissue, testing for the effects of various agents on the growth and differentiation of the tissue, as well as identification of agents involved with the growth and differentiation.

Abstract translation: 原始组织被引入免疫缺陷型宿主，其中原始组织发育和分化。 嵌合宿主允许调查异种组织的过程和发展，测试各种药剂对组织生长和分化的影响，以及鉴定参与生长和分化的药剂。