公开(公告)号：WO2021026495A1

公开(公告)日：2021-02-11

申请号：PCT/US2020/045485

申请日：2020-08-07

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： DHURANDHAR, Nikhil, V. ,  HEGDE, Vijay

IPC: C12N7/00 ,  A61K48/00 ,  C12N15/86 ,  C07F5/02 ,  A61P25/14

Abstract: Embodiments of the present disclosure pertain to methods of treating or preventing Alzheimer's disease or symptoms of Alzheimer's disease in a subject by administering to the subject an active agent that includes an adenovirus-36 E4orf1 protein, a nucleic acid encoding an adenovirus-36 E4orfl protein, or combinations thereof. Additional embodiments of the present disclosure pertain to the active agents of the present disclosure for use in the treatment or prevention of Alzheimer's disease or symptoms of Alzheimer's disease.

公开(公告)号：WO2020146449A1

公开(公告)日：2020-07-16

申请号：PCT/US2020/012663

申请日：2020-01-08

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： DHURANDHAR, Nikhil, V. ,  DAS, Bhaskar, C.

IPC: A61K38/18 ,  A61K8/19 ,  A61K38/28

Abstract: In an embodiment, the present disclosure pertains to compositions and methods for modulating cellular glucose uptake. In general, the methods include associating cells with the compositions of the present disclosure. In another aspect, the present disclosure pertains to compositions and methods to treat or prevent a disorder in a subject. The methods generally include administering the compositions of the present disclosure to the subject.