公开(公告)号：WO2023014293A2

公开(公告)日：2023-02-09

申请号：PCT/SG2022/050532

申请日：2022-07-26

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

发明人： HU, Yuwei ,  YING, Jackie Yi-Ru

IPC分类号： A61K9/06 ,  A61K47/32 ,  A61K38/28 ,  A61K47/26 ,  C08F220/56 ,  C08J3/075 ,  A61K9/0019 ,  A61K9/0053

摘要： There is provided a pH-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a pH-responsive composition, the composition comprising, a copolymer comprising, a backbone moiety; and a plurality of side moieties grafted to the backbone moiety, the plurality of side moieties comprising at least one adenine-rich (A-rich) oligonucleotide and at least one cytosine-rich (C-rich) oligonucleotide; wherein the copolymer is configured to form a hydrogel when exposed to an environment with a pH falling in a first range of pH values, thereby facilitating encapsulation of the cargo within the hydrogel; and wherein the copolymer is configured to form a solution when exposed to an environment with a pH falling in a second range of pH values different from the first range of pH values, thereby facilitating release of the cargo.

公开(公告)号：WO2023286120A1

公开(公告)日：2023-01-19

申请号：PCT/JP2021/026117

申请日：2021-07-12

申请人： 国立大学法人九州大学

发明人： 後藤　雅宏 ,  若林　里衣

IPC分类号： A61K47/12 ,  A61K9/10 ,  A61K38/02 ,  A61K38/28 ,  A61K47/14 ,  A61K47/18

摘要： 経皮吸収剤は、イオン液体が油相中に微分散している経皮吸収剤であって、前記イオン液体は、親水性ペプチド薬と、コリンと、脂肪酸のカルボキシ基から水素イオンが解離したカルボキシラートイオンと、を含む。前記油相中に微分散している前記イオン液体の平均粒子径が１ｎｍ以上１００ｎｍ以下であってもよい。前記油相中に微分散している前記イオン液体の粒子の中心部が、親水性ペプチド薬と、プロピオン酸コリン、乳酸コリン、及びギ酸コリンからなる群より選ばれる１種以上と、からなってもよい。前記親水性ペプチド薬がインスリンであってもよい。前記脂肪酸がオレイン酸又はリノール酸であってもよい。前記経皮吸収剤は、前記油相中にモノラウリン酸ソルビタンを更に含んでもよい。

公开(公告)号：WO2023285357A1

公开(公告)日：2023-01-19

申请号：PCT/EP2022/069278

申请日：2022-07-11

申请人： FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  IRCCS "OSPEDALE POLICLINICO SAN MARTINO"

发明人： PRIMAVERA, Rosita ,  DECUZZI, Paolo ,  THAKOR, Avnesh S. ,  DEPASCALE, Angelo

IPC分类号： A61K47/69 ,  A61K47/54 ,  A61K47/62 ,  A61K38/28 ,  A61K9/14 ,  A61P3/10

摘要： The invention relates to a glucose-sensitive insulin-loaded microparticle comprising a polymeric porous matrix made of a biocompatible and biodegradable polymer, insulin granules encapsulated within the polymeric porous matrix, and a blood glucose sensor attached to a surface of the microparticle. In one embodiment, the biocompatible and biodegradable polymer is poly(lactic-co-glycolic) acid (PLGA) and the blood glucose sensor is glucose oxidase or phenylboronic acid. The invention also relates to the use of the glucose-sensitive insulin-loaded microparticle for the therapeutic treatment of diabetes and for controlling glucose levels in the blood of a subject in need thereof.

公开(公告)号：WO2023283393A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/036439

申请日：2022-07-08

申请人： GILA THERAPEUTICS, INC.

发明人： VASICEK, Thomas

IPC分类号： A61K41/00 ,  A61K38/28

摘要： The invention provides methods for inducing satiety and treatment of metabolic disorders, diabetes, obesity, and obesity-related conditions. The methods include administration of a metabolic hormone via an intranasal, topical gastrointestinal, or intrarectal route.

公开(公告)号：WO2022272019A8

公开(公告)日：2022-12-29

申请号：PCT/US2022/034836

申请日：2022-06-24

申请人： GILA THERAPEUTICS, INC.

发明人： VASICEK, Thomas

IPC分类号： A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  A61K38/28 ,  A61K38/16 ,  A61K38/26

摘要： The invention provides methods and kits for inducing satiety and treatment of metabolic disorders, diabetes, obesity, and obesity-related conditions. The methods and kits herein described include administration of a metabolic hormone and a GLP-1 receptor agonist for inducing satiety or treatment of metabolic syndrome, diabetes, obesity, and obesity-related disorders.

公开(公告)号：WO2022268941A1

公开(公告)日：2022-12-29

申请号：PCT/EP2022/067148

申请日：2022-06-23

申请人： NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)

发明人： CARLSEN, Sven Magnus ,  CHRISTIANSEN, Sverre Christian ,  FOUGNER, Anders Lyngvi ,  STAVDAHL, Øyvind ,  ELLINGSEN, Reinold ,  HJELME, Dag Roar

IPC分类号： A61K38/26 ,  A61K38/28 ,  A61P3/10 ,  A61P5/50 ,  A61B5/145 ,  A61M5/172 ,  A61M31/00 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/6848 ,  A61M2005/1726

摘要： The present invention relates to a novel medical use of glucagon, and other compounds with glucagon activity, as vasodilators, to assist in the delivery of therapeutic agents or in the operation of sensor devices which determine the level of analytes in the blood. In particular, the compound is administered in temporal coordination with the active agent and/or in conjunction with determination of the analyte by a bodily sensor, and at a site which is in the vicinity of the site of administration of the active agent and/or of the site(s) of sensing of the analyte by the bodily sensor. This includes in particular the delivery of insulin in the treatment of diabetes, and the determination of blood glucose levels by glucose sensors. Also provided herein are integrated systems for performing the medical uses and therapies.

公开(公告)号：WO2022163852A1

公开(公告)日：2022-08-04

申请号：PCT/JP2022/003677

申请日：2022-01-31

申请人： 株式会社　バイオミメティクスシンパシーズ

发明人： 漆畑　直樹 ,  隠岐　勝幸 ,  吉原　誠一 ,  大西　啓介

IPC分类号： A61K45/00 ,  A61K48/00 ,  A61P5/48 ,  A61P31/14 ,  A61P43/00 ,  C12N15/09 ,  C12N15/16 ,  A61K38/18 ,  A61K38/28 ,  A61K31/47 ,  A61K31/4706 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K14/62 ,  C07K14/65

摘要： アンジオテンシン転換酵素２（ＡＣＥ２）及び／又はＴＭＰＲＳＳ２の発現を阻害するための組成物を提供すること。アンジオテンシン転換酵素２（ＡＣＥ２）及び／又はＴＭＰＲＳＳ２の発現を阻害するための組成物であって、前記組成物は、ＦｏｘＯ１阻害剤を含む、組成物。

公开(公告)号：WO2022132712A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063235

申请日：2021-12-14

申请人： ELI LILLY AND COMPANY

发明人： CARR, Molly Corbett ,  CHIEN, Yueh-Ling a/k/a Jenny Y. CHIEN ,  CHIGUTSA, Emmanuel ,  GARHYAN, Parag ,  HAUPT, Axel Richard Karl-August ,  TANG, Cheng Cai

IPC分类号： A61K38/28 ,  A61P3/10 ,  A61M5/315 ,  A61K47/26

摘要： Described herein are fixed doses and dosing regimens for long-acting insulin receptor agonists suitable for once-weekly dosing, such as weekly basal insulin-Fc (BIF).

公开(公告)号：WO2022111439A1

公开(公告)日：2022-06-02

申请号：PCT/CN2021/132291

申请日：2021-11-23

申请人： 南京鼓楼医院

发明人： 赵远锦 ,  蔡丽均 ,  王月桐 ,  商珞然

IPC分类号： A61K38/28 ,  A61K9/00 ,  A61K47/42 ,  A61K47/02 ,  A61P3/10

摘要： 一种胃部靶标口服大分子载体及其制备方法，口服大分子载体包括连续的负载药物的微针组件和负载燃料的尾翼组件；微针组件为圆锥形的针尖，尾翼组件相接于微针组件的圆锥底面，且向外侧突出于圆锥底面，从而在载体突破胃黏膜屏障时避免穿孔；微针组件由混有大分子药物的水凝胶预溶液固化而成；尾翼组件由混有燃料物质的水凝胶预溶液固化而成。具有制备过程简单、成本低、通用性高等优点。

公开(公告)号：WO2022066825A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/051628

申请日：2021-09-23

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： MOON, James J. ,  HAN, Kai ,  XIE, Fang ,  ZHOU, Xingwu

IPC分类号： A61K38/28 ,  A61K39/395 ,  A61K9/14

摘要： This invention relates generally to compositions comprising a gel-based inulin formulation associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) one or more therapeutic agents (e.g., immunomodulatory agent, immunosuppressant, allergen) and related methods for the treatment of autoimmune disorders (e.g., colitis) (e.g, allergy, such as food allergy). Also provided herein are compositions and methods for modulating an immune response associated with an autoimmune disorder (e.g., allergy) and/or inducing immune tolerance or desensitization to an autoimmune disorder (e.g., allergy, such as a food allergy).