公开(公告)号：WO2022240936A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028695

申请日：2022-05-11

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： REID, Ted, W. ,  FRALICK, Joe ,  TRAN, Phat, L. ,  BERFELD, Nicholas ,  SUNDIN, Olof

IPC: G01N33/553 ,  A61K31/095 ,  A61K33/04 ,  A61K33/08 ,  A61K33/24 ,  A61K47/50

Abstract: The present invention includes composition and methods for making and using a selenium-carrier conjugate for in vivo administration comprising: covalently attaching a selenium compound that reacts in vivo with naturally occurring reduced thiols and oxygen to produce superoxide, which can include a Fenton Complex that allows for a generation of hydroxyl radicals, and that wherein the selenium-carrier conjugate is stabilized against enzymatic degradation and clearance from the body and the synthetic targeting carrier binds target.