公开(公告)号：WO2022240936A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028695

申请日：2022-05-11

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： REID, Ted, W. ,  FRALICK, Joe ,  TRAN, Phat, L. ,  BERFELD, Nicholas ,  SUNDIN, Olof

IPC: G01N33/553 ,  A61K31/095 ,  A61K33/04 ,  A61K33/08 ,  A61K33/24 ,  A61K47/50

Abstract: The present invention includes composition and methods for making and using a selenium-carrier conjugate for in vivo administration comprising: covalently attaching a selenium compound that reacts in vivo with naturally occurring reduced thiols and oxygen to produce superoxide, which can include a Fenton Complex that allows for a generation of hydroxyl radicals, and that wherein the selenium-carrier conjugate is stabilized against enzymatic degradation and clearance from the body and the synthetic targeting carrier binds target.

公开(公告)号：WO2022182544A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/016371

申请日：2022-02-15

Applicant: CORNING INCORPORATED

Inventor： COON, Erin ,  FU, Qiang ,  LI, Aize

IPC: A61K33/00 ,  A61K33/08 ,  A61K33/16

Abstract: A silicate-based glass composition includes 15-65 wt.% SiO2, 2.5-25 wt.% MgO, 1-30 wt.% P2O5, and 15-50 wt.% CaO. The glass composition may also include 0-5 wt.% F-, and 0-10 wt.% ZrO2. The glass composition may also include one of 0-10 wt.% Al2O3, 0-10 wt.% SrO, and 0-10 wt.% ZnO.

公开(公告)号：WO2021250236A1

公开(公告)日：2021-12-16

申请号：PCT/EP2021/065768

申请日：2021-06-11

Applicant: UNIVERSITAT INTERNACIONAL DE CATALUNYA, FUNDACIÓ PRIVADA ,  UNIVERSITAT DE BARCELONA

Inventor： DURÁN-SINDREU TEROL, Fernando Salvador ,  GONZÁLEZ SÁNCHEZ, José Antonio ,  PÉREZ ANTOÑANZAS, Román ,  ELMSMARI, Firas ,  SÁNCHEZ LÓPEZ, Elena ,  GARCÍA LÓPEZ, María Luisa

IPC: A61K9/51 ,  A61C5/50 ,  A61K6/54 ,  A61K6/849 ,  A61K33/08 ,  A61P1/02 ,  A61P31/04 ,  A61K6/56 ,  A61K9/19 ,  A61K9/5153 ,  A61K9/5192

Abstract: A composition comprising nanoparticles, a method for the preparation of a composition comprising nanoparticles and uses of the composition for dental treatment are provided. Each nanoparticle is made of polymeric material and includes an antimicrobial agent encapsulated therein. The polymeric material can include Poly(lactic-co-glycolic acid) (PLGA), or other polymers such as Polylactic (PLA), Polyglycolic (PGA), or Polycaprolactone (PCL). The active molecule is calcium hydroxide in the range of 0.1 to 5 mg/ml. The composition has a pH in the range of 8 – 13.

公开(公告)号：WO2021145755A1

公开(公告)日：2021-07-22

申请号：PCT/KZ2020/000029

申请日：2020-12-04

Applicant: ЛУРЬЕ, Арман Женисович

Inventor： ЛУРЬЕ, Арман Женисович LURYE, Arman Zhenisovich

IPC: A61K9/08 ,  A61K31/616 ,  A61K31/727 ,  A61K35/745 ,  A61K8/25 ,  A61K31/454 ,  A61P7/00 ,  A61K2035/115 ,  A61K31/137 ,  A61K31/194 ,  A61K31/353 ,  A61K31/5377 ,  A61K31/60 ,  A61K31/695 ,  A61K31/7004 ,  A61K33/08 ,  A61K33/14 ,  A61K33/30 ,  A61K9/0053

Abstract: Изобретение относится к медицине и может быть использовано для уменьшения негативного влияния авиаперелетов на здоровье человека. Способ включает прием препаратов, повышающих осмолярность плазмы крови. Принимают внутрь водный раствор для пероральной регидратации, разделенный на два приема. Первый прием - в количестве не менее 0,3 л. до 1 л. перед посадкой в самолет, и далее в самолете - в интервале от получаса до 2-х часов не менее 0,3 л. до 1 л. и по мере возникновения жажды. Дополнительно за 20-30 минут перед полетом принимают разовую дозу антикоагулянта, а также пробиотики и пеногасители. Способ позволяет синергетически уменьшить негативное влияние перелета на здоровье человека, избежать состояния джетлага, отеков ног, болей в животе.

公开(公告)号：WO2021107824A1

公开(公告)日：2021-06-03

申请号：PCT/RU2020/050354

申请日：2020-11-27

Applicant: БАТОМУНКУЕВ, АНДРЕЙ ВЛАДИМИРОВИЧ ,  КАРДАКОВА, АНАСТАСИЯ АЛЕКСАНДРОВНА ,  РОМАНОВ, БОРИС АЛЕКСАНДРОВИЧ ,  ОРЛОВ, ВЛАДИМИР НИКОЛАЕВИЧ

Inventor： БАТОМУНКУЕВ, АНДРЕЙ ВЛАДИМИРОВИЧ BATOMUNKUEV, Andrey Vladimirovich

IPC: A61N5/06 ,  A61K33/08 ,  A61K38/41 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61P1/02 ,  A61M35/00

Abstract: Изобретение относится к медицине, а именно к стоматологии и может быть использовано для профилактики и лечения воспалительных заболеваний полости рта, в частности пародонтита. Способ обеспечивает эффективное, безопасное лечение воспалительных заболеваний полости рта за счет фотодинамической терапии полости рта и нанесения стоматологического геля-фотосенсибилизатора на обрабатываемые участки.

公开(公告)号：WO2021007062A1

公开(公告)日：2021-01-14

申请号：PCT/US2020/040113

申请日：2020-06-29

Applicant: UOP LLC

Inventor： LEWIS, Gregory John ,  JAKUBCZAK, Paulina ,  MARTE, Julio C. ,  SHEETS, William Christopher

IPC: A61K33/08 ,  A61M1/18 ,  A61P39/04

Abstract: A process for removing Co 2+ , Pb 2+ , Cd 2+ and Cr 3+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: A m Zr a Ti b Sn c M d Si x O y . A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

公开(公告)号：WO2020035163A1

公开(公告)日：2020-02-20

申请号：PCT/EP2019/000214

申请日：2019-07-12

Applicant: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH)

Inventor： JOCKENHÖVEL, Stefan ,  CORNELISSEN, Christian ,  SPILLNER, Jan ,  JAN KOK, Robbert

IPC: A61K9/16 ,  A61K9/50 ,  A61P11/00 ,  A61K33/08

Abstract: Disclosed is a composition of 10 wt% to 99 wt% of carbon dioxide absorbent or adsorbent, wherein the carbon dioxide absorbent or adsorbent is selected from the group consisting of inorganic hydroxides of alkali hydroxides and/or alkaline earth metal hydroxides, molecular sieves, zeolites, zinc (ii) ions, deep eutectic solvents and/or silica, whereby the composition contains 1 wt% to 90 wt%, relative to the total composition, of a polymeric coating selected from the group consisting of silicone rubber obtained from liquid silicone rubber and cellulose derivative for use in medicine for the prophylaxis and treatment of respiratory diseases in a mammal.

公开(公告)号：WO2019140319A1

公开(公告)日：2019-07-18

申请号：PCT/US2019/013371

申请日：2019-01-11

Applicant: COLONARYCONCEPTS LLC

Inventor： ALLIO, Michael K. ,  SIEGEL, Corey A. ,  KORZENIK, Joshua

IPC: A23L33/10 ,  A23L33/21 ,  A61K31/70 ,  A61K31/375 ,  A61K31/765 ,  A61K33/08 ,  A61K33/42

Abstract: Described herein are compositions and methods that, in some embodiments, are specifically configured to treat different types of constipation. In particular, described herein are compositions and methods for treating IBS-C, opioid induced constipation, and chronic idiopathic constipation. In addition to treating the symptom of constipation, these embodiments of the compositions and methods described herein are configured to address specific etiologies and/or pathophysiologies associated with the constipation types of IBS-C, opioid induced constipation, and chronic idiopathic constipation.

公开(公告)号：WO2016178492A3

公开(公告)日：2017-01-05

申请号：PCT/KR2016004525

申请日：2016-04-29

Applicant: LEE JONG DOO

Inventor： LEE JONG DOO

IPC: A61K35/02 ,  A61K9/02 ,  A61K33/06 ,  A61K33/08 ,  B01D11/02

CPC classification number: A61K9/02 ,  A61K33/06 ,  A61K33/08 ,  A61K35/02 ,  B01D11/02

Abstract: The present invention provides a method for preparing a multifunctional natural gel by using mineral-based somatids extracted from a naturally produced mineral, comprising: (a) a powder reheating step of reheating mineral-based somatids at a predetermined high temperature in order to culture mineral-based somatids in the mineral-based somatids; (b) a mineral-based somatids separation step of mixing the mineral-based somatids heated in step (a) and water or distilled water in a predetermined ratio, and separating mineral-based somatids from the mineral-based somatids separated into an upper layer part, a middle layer part and a lower layer part through a stirrer and a centrifuge; and (c) a naturel gel preparation step of evaporating water or distilled water by heating the middle layer part separated in step (b) at a predetermined temperature, extracting only the remaining pure mineral-based somatid, and then preparing a gel-type natural gel from the extracted pure mineral-based somatid.

Abstract translation: 本发明提供了一种通过使用从天然产生的矿物中提取的矿物质的小球体制备多功能天然凝胶的方法，其包括：（a）粉末再加热步骤，在预定的高温下再加热基于矿物的小球体以培养矿物质 基于矿物的somatids的基于的somatids; （b）基于矿物质的somatids分离步骤，其中将步骤（a）中加热的矿物基质的实生植物与水或蒸馏水以预定的比例混合，并将矿物质的somatids与分离成上层的矿物质somatids分离 部分，中间层部分和下层部分通过搅拌器和离心机; （c）通过在预定温度下加热步骤（b）中分离出的中间层部分来蒸发水或蒸馏水的自然凝胶制备步骤，仅提取剩余的纯矿物质基体细胞体，然后制备凝胶型天然 来自提取的纯矿物质体细胞的凝胶。

公开(公告)号：WO2016042831A1

公开(公告)日：2016-03-24

申请号：PCT/JP2015/062926

申请日：2015-04-30

Applicant: 協和化学工業株式会社

Inventor： 吉村　勇哉

IPC: A61K33/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K31/047 ,  A61K31/702 ,  A61K49/00 ,  A61P1/10 ,  A61P43/00

CPC classification number: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K31/047 ,  A61K31/702 ,  A61K33/08 ,  A61K49/00

Abstract: 　酸化マグネシウム粒子を主成分とした優れた腸管洗浄効果を有する大腸の検査または手術のための処置用製剤を提供すること。　大腸検査または手術のための処置用製剤であって、その処置用製剤は酸化マグネシウム粒子、難消化性オリゴ糖および糖アルコールを組み合わせることによって、効果的に大腸の内容物の含水量を高め、便の流動性および腸の洗浄効果ならびに検査の精度を向上させた大腸検査または手術の前に経口投与のために用いられるものである処置用製剤。

Abstract translation: 本发明提供一种用于大肠试验或手术治疗的制剂，其含有氧化镁颗粒作为主要成分，具有优异的肠道灌洗效果。 用于治疗目的用于大肠测试或手术的准备。 用于治疗目的的制剂包括氧化镁颗粒，难消化的寡糖和糖醇的组合，并且可以有效地增加大肠中的含量的水量，可以提高粪便的流动性，肠灌洗效果和 测试的准确性，并且可以在大肠的测试或手术之前用于口服给药。