公开(公告)号：WO2023087029A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/079899

申请日：2022-11-15

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： GAO, Jinming ,  HUANG, Gang ,  SUN, Zhichen ,  FENG, Qiang ,  LI, Wei

IPC: A61K31/12 ,  A61K9/00 ,  A61K9/127 ,  C08F293/00 ,  A61K47/62 ,  A61K9/107

Abstract: Ultra pH sensitive (UPS) micelles encapsulating cytokines are provided that provide lower toxicity and higher efficacy compositions and methods for treating cancer with those compositions.

公开(公告)号：WO2020263733A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/038915

申请日：2020-06-22

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： GAO, Jinming ,  WANG, Xu ,  TANG, Houliang ,  LI, Wei ,  WILHELM, Jonathan ,  SUMER, Baran

IPC: A61K47/34 ,  C08G65/48 ,  C08L71/02

Abstract: The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo . In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.