公开(公告)号：WO2016085657A1

公开(公告)日：2016-06-02

申请号：PCT/US2015/060139

申请日：2015-11-11

申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI ,  CLEMSON UNIVERSITY

发明人： MA, Yinfa ,  SHI, Honglan ,  YANG, Qingbo ,  XIAO, Hai

IPC分类号： G01N21/64 ,  G01N33/53 ,  G01K13/00

CPC分类号： G01N21/6428 ,  G01N21/645 ,  G01N21/7703 ,  G01N21/80 ,  G01N31/221 ,  G01N2021/772 ,  G01N2021/7786 ,  G01N2201/0636

摘要： A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmitting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.

摘要翻译： pH微探针，温度微探针和基于免疫的微探针各自包括用于传输输入光信号的轴和用于插入电池或用于测量pH，温度和/或 抗原。 pH微探针和温度微探针各自包括位于微探针尖端上的发光材料。 光信号激发发光材料，使得发光材料发出发光光信号。 发光光信号具有取决于被测量的pH或温度的特性值，并且经由轴反射以通过光信号测量装置测量。 基于免疫的微探针包括具有取决于存在于反射材料上的抗原 - 抗体结合数目的有效折射率的反射材料。