公开(公告)号：WO2018108070A1

公开(公告)日：2018-06-21

申请号：PCT/CN2017/115629

申请日：2017-12-12

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： TANG, Benzhong ,  QI, Ji ,  CHEN, Ming ,  QIN, Wei ,  ZHANG, Pengfei

IPC: C07D241/24 ,  C07D487/02 ,  C07D513/02 ,  C07D515/02 ,  C07D517/02 ,  C09K11/00 ,  H01L51/50

Abstract: A compound comprises a donor and an acceptor, wherein at least one donor ( "D" ) and at least one acceptor ( "A" ) may be arranged in an order of D-A; D-A-D; A-D-A; D-D-A-D-D; A-A-D-A-A; D-A-D-A-D; and A-D-A-D-A. The compound may be selected from the group consisting of: MTPE-TP, MTPE-TT, TPE-TPA-TT, PTZ-BT-TPA, NPB-TQ, TPE-TQ-A, MTPE-BTSe, DCDPP-2TPA, DCDPP-2TPA4M, DCDP-2TPA, DCDP-2TPA4M, TTS, ROpen-DTE-TPECM, and RClosed-DTE-TPECM. The compound may be used as a probe and may be functionalized with special targeted groups to image biological species. As non-limiting examples, the compound may be used in cellular cytoplasms or tissue imaging, blood vessel imaging, in vivo fluorescence imaging, brain vascular imaging, sentinel lymph node mapping, and tumor imaging, and the compound may be used as a photoacoustic agent.

公开(公告)号：WO2013029340A9

公开(公告)日：2013-03-07

申请号：PCT/CN2012/001227

申请日：2012-09-03

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  NATIONAL UNIVERSITY OF SINGAPORE ,  TANG, Benzhong ,  QIN, Wei ,  LIU, Jianzhao ,  CHEN, Sijie ,  KWOK, Tsz Kin ,  LIU, Bin ,  LI, Kai ,  DING, Dan ,  SHI, Haibin ,  GENG, Jun Long ,  SUN, Jingzhi ,  QIN, Anjun ,  ZHAO, Qiuli

Inventor： TANG, Benzhong ,  QIN, Wei ,  LIU, Jianzhao ,  CHEN, Sijie ,  KWOK, Tsz Kin ,  LIU, Bin ,  LI, Kai ,  DING, Dan ,  SHI, Haibin ,  GENG, Jun Long ,  SUN, Jingzhi ,  QIN, Anjun ,  ZHAO, Qiuli

IPC: C09K11/06

Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

公开(公告)号：WO2015163817A1

公开(公告)日：2015-10-29

申请号：PCT/SG2015/000123

申请日：2015-04-24

Applicant: NATIONAL UNIVERSITY OF SINGAPORE ,  THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： LIU, Bin ,  YUAN, Youyong ,  FENG, Guangxue ,  TANG, Ben Zhong ,  QIN, Wei ,  ZHANG, Chongjing ,  XU, Shidang

IPC: C07C15/52 ,  G01N33/52 ,  C09K11/06 ,  C07D285/14 ,  C07D309/34 ,  A61K31/015 ,  A61K31/282

CPC classification number: G01N33/5011 ,  A61K9/4866 ,  A61K41/0042 ,  A61K49/0056 ,  A61K2121/00 ,  A61K2123/00 ,  C07C255/43 ,  C07D285/14 ,  C07D309/34 ,  C09B23/0058 ,  C09B23/06 ,  C09B23/141 ,  C09B57/008 ,  C09B69/103 ,  C09B69/109 ,  C09K11/06 ,  C09K11/07 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1051 ,  C09K2211/1088 ,  G01N33/582

Abstract: A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.

Abstract translation: 本文描述了具有聚合诱导的发射特性的荧光团或共轭聚合物，其用于药物跟踪和递送，生物学对象的鉴定和标记，例如细胞或细胞部分，以及用于成像和图像引导的光动力学治疗。