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    LUMINOGENS FOR BIOLOGICAL APPLICATIONS
    2.
    发明申请
    LUMINOGENS FOR BIOLOGICAL APPLICATIONS 审中-公开

    公开(公告)号：WO2018108070A1

    公开(公告)日：2018-06-21

    申请号：PCT/CN2017/115629

    申请日：2017-12-12

    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： TANG, Benzhong ,  QI, Ji ,  CHEN, Ming ,  QIN, Wei ,  ZHANG, Pengfei

    IPC: C07D241/24 ,  C07D487/02 ,  C07D513/02 ,  C07D515/02 ,  C07D517/02 ,  C09K11/00 ,  H01L51/50

    Abstract: A compound comprises a donor and an acceptor, wherein at least one donor ( "D" ) and at least one acceptor ( "A" ) may be arranged in an order of D-A; D-A-D; A-D-A; D-D-A-D-D; A-A-D-A-A; D-A-D-A-D; and A-D-A-D-A. The compound may be selected from the group consisting of: MTPE-TP, MTPE-TT, TPE-TPA-TT, PTZ-BT-TPA, NPB-TQ, TPE-TQ-A, MTPE-BTSe, DCDPP-2TPA, DCDPP-2TPA4M, DCDP-2TPA, DCDP-2TPA4M, TTS, ROpen-DTE-TPECM, and RClosed-DTE-TPECM. The compound may be used as a probe and may be functionalized with special targeted groups to image biological species. As non-limiting examples, the compound may be used in cellular cytoplasms or tissue imaging, blood vessel imaging, in vivo fluorescence imaging, brain vascular imaging, sentinel lymph node mapping, and tumor imaging, and the compound may be used as a photoacoustic agent.

    HISTONE DEMENTHYLASE INHIBITORS
    4.
    发明申请
    HISTONE DEMENTHYLASE INHIBITORS 审中-公开
    HISTONE DEMENTHYLASE抑制剂

    公开(公告)号：WO2014164708A1

    公开(公告)日：2014-10-09

    申请号：PCT/US2014/023273

    申请日：2014-03-11

    Applicant: QUANTICEL PHARMACEUTICALS, INC.

    Inventor： CHEN, Young, K. ,  WALLACE, Michael, Brennan

    IPC: A61K31/4365 ,  C07D513/02

    CPC classification number: C07D471/04

    Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

    Abstract translation: 本发明一般涉及用于治疗癌症和肿瘤性疾病的组合物和方法。 本文提供取代的吡咯并吡啶衍生物化合物和包含所述化合物的药物组合物。 主题化合物和组合物可用于抑制组蛋白去甲基化酶。 此外，本发明化合物和组合物可用于治疗癌症，例如前列腺癌，乳腺癌，膀胱癌，肺癌和/或黑素瘤等。

    COMPOUNDS HAVING PROGESTOGENIC ACTIVITY AND THEIR USE
    9.
    发明申请
    COMPOUNDS HAVING PROGESTOGENIC ACTIVITY AND THEIR USE 审中-公开
    具有致孕活性的化合物及其用途

    公开(公告)号：WO2006107273A8

    公开(公告)日：2006-12-28

    申请号：PCT/SG2005000116

    申请日：2005-04-06

    Applicant: UNIV SINGAPORE ,  YONG EU LEONG ,  LIM LIS SA ELISSA ,  SHEN PING ,  GONG YINHAN

    Inventor： YONG EU LEONG ,  LIM LIS SA ELISSA ,  SHEN PING ,  GONG YINHAN

    IPC: A61K31/343 ,  A61K31/381 ,  A61K31/407 ,  A61K36/00 ,  A61P5/30 ,  C07D487/02 ,  C07D491/02 ,  C07D493/22 ,  C07D495/02 ,  C07D497/02 ,  C07D498/02 ,  C07D513/02

    CPC classification number: A61K36/236 ,  A61K31/343 ,  A61K31/381 ,  A61K31/407 ,  C07D493/04 ,  C07D493/10

    Abstract: The invention relates to compounds having progestogenic activity and to their use. The invention discloses a compound having the general formula (I) wherein Y, Y', X and X' are independently selected from the group consisting of O, S and N; R 1 is selected from the group consisting of optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C4-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally substituted C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 )alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 5 -C 10 )aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are independently selected from the group consisting of hydrogen, optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally substituted C 1-6 thioalkyl, optionally substituted C 5-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally substituted C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 )alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 5 -C 10 )aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; ---- indicates an optional double bond.

    Abstract translation: 本发明涉及具有孕激素活性的化合物及其用途。 本发明公开了具有通式（I）的化合物，其中Y，Y'，X和X'独立地选自O，S和N; R 1选自任选取代的C 1-8烷基，任选取代的C 2-6烯基，任选取代的C 1-6烷基， 炔基，任选取代的C 1-6烷氧基，任选取代的C 1-6硫代烷基，任选取代的C 4-10芳基，任选取代的C 6-12芳基， 烷基芳基，任选取代的C 1-6烷基氨基，任选取代的C 1-6烷基羰基，任选取代的C 1-6烷基磺酰氨基， 任选取代的（C 1 -C 6）烷基亚磺酰基，任选取代的C 1-6烷基羰基氨基，任选取代的杂（C 5 -C 5） 芳基，羟基，卤素，氰基，硝基，氨基，甲酰基和巯基; R SUB 3，SUB 3，SUB 4，SUB 5，SUB 6，SUB和 R 7独立地选自氢，任选取代的C 1-8烷基，任选取代的C 2-6烯基，任选取代的 取代的C 2-6炔基，任选取代的C 1-6烷氧基，任选取代的C 1-6硫代烷基，任选取代的C≡C1-6烷基， 5-10芳基，任选取代的C 6-11烷基芳基，任选取代的C 1-6烷基氨基，任选取代的C 1-6烷基， 任选取代的C 1-6烷基磺酰氨基，任选取代的（C 1 -C 6）烷基亚磺酰基，任选取代的C 1 -C 4烷基磺酰基， 任选取代的杂芳基，羟基，卤素，氰基，硝基，氨基，甲酰基和巯基; ----表示可选的双键。

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