公开(公告)号：WO2016126947A2

公开(公告)日：2016-08-11

申请号：PCT/US2016/016573

申请日：2016-02-04

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： SADTLER, Kaitlyn ,  ALLEN, Brian ,  ELISSEEFF, Jennifer ,  GARZA, Luis

IPC分类号： A61K31/728 ,  A61K47/30 ,  A61K47/36 ,  A61K9/00 ,  A61P17/14

CPC分类号： A61K31/728 ,  A61K9/0019 ,  A61K9/0021 ,  A61K47/36 ,  A61L27/20 ,  A61L27/3633 ,  A61L27/3813 ,  A61K2300/00 ,  C08L5/08

公开(公告)号：WO2021087082A1

公开(公告)日：2021-05-06

申请号：PCT/US2020/057912

申请日：2020-10-29

申请人： THE JOHNS HOPKINS UNIVERSITY ,  INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I.

发明人： SLUSHER, Barbara ,  ISLAM, Mohameed ,  RAIS, Rana ,  GARZA, Luis ,  BELL, Benjamin ,  MAJER, Pavel ,  TENORA, Lukas ,  SNAJDR, Ivan ,  KRECMEROVA, Marcela

IPC分类号： A61K31/167 ,  A61K31/17 ,  A61K31/196

摘要： Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.

公开(公告)号：WO2021087083A1

公开(公告)日：2021-05-06

申请号：PCT/US2020/057913

申请日：2020-10-29

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： GARZA, Luis ,  ISLAM, Mohameed ,  SLUSHER, Barbara ,  RAIS, Rana

IPC分类号： A61K31/167 ,  A61K31/17 ,  A61K31/196

摘要： Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed.

公开(公告)号：WO2012154773A2

公开(公告)日：2012-11-15

申请号：PCT/US2012/037005

申请日：2012-05-09

申请人： THE JOHNS HOPKINS UNIVERSITY ,  KANG, Sewon ,  DORFMAN, Danielle Nicole ,  DING, Yifu ,  SHAH, Chirag ,  HARWELL, Andrew S. ,  KELLY, Marie ,  CHIEN, Anna ,  GARZA, Luis ,  TAUBE, Janis

发明人： KANG, Sewon ,  DORFMAN, Danielle Nicole ,  DING, Yifu ,  SHAH, Chirag ,  HARWELL, Andrew S. ,  KELLY, Marie ,  CHIEN, Anna ,  GARZA, Luis ,  TAUBE, Janis

IPC分类号： A61B10/02 ,  A61B17/32

CPC分类号： A61B10/0266 ,  A61B10/0233 ,  A61B17/3205 ,  A61B2017/00747 ,  A61B2017/00907 ,  A61B2017/320064

摘要： An embodiment in accordance with the present invention provides a device for performing a skin biopsy that includes a generally curved blade to cut the skin at a predetermined depth disposed within or an integral part of a blade holder assembly. The blade holder assembly has an outer surface and the generally curved blade is coupled to the outer surface of the blade holder assembly. The device also includes a housing having an outer wall and said outer wall defining an interior space within the housing, such that the blade holder assembly and generally curved blade are disposed substantially within the inner space of the housing. The device also includes a handle coupled to the blade holder assembly and configured to rotate the blade holder assembly and in turn the generally curved blade within the inner space of the housing to perform the skin biopsy or removal of skin conditions.

摘要翻译： 根据本发明的实施例提供了一种用于进行皮肤活检的装置，其包括大致弯曲的刀片，以在设置在刀片保持器组件内或整体部分中的预定深度处切割皮肤。 刀片保持器组件具有外表面，并且大致弯曲的刀片联接到刀片保持器组件的外表面。 该装置还包括壳体，其具有外壁，并且所述外壁限定在壳体内的内部空间，使得刀片保持器组件和大体上弯曲的刀片基本上设置在壳体的内部空间内。 该装置还包括与刀片保持器组件联接的手柄，并且构造成使刀片保持器组件旋转，并且在壳体的内部空间内旋转大致弯曲的刀片，以执行皮肤活检或皮肤状态的去除。

公开(公告)号：WO2021202530A

公开(公告)日：2021-10-07

申请号：PCT/US2021/024889

申请日：2021-03-30

申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]

发明人： GARZA, Luis ,  MILLER, Lloyd ,  ALPHONSE, Martin ,  ISLAM, Mohameed

IPC分类号： A61K38/55 ,  A61P1/00 ,  A61P17/02 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14

摘要： The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.