公开(公告)号：WO2022006055A1

公开(公告)日：2022-01-06

申请号：PCT/US2021/039526

申请日：2021-06-29

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： SCHULMAN, Rebecca B. ,  JIA, Sisi ,  PHUA, Siew Cheng ,  NIHONGAKI, Yuta ,  LI, Yizeng ,  PACELLA, Michael ,  LI, Yi ,  MOHAMMED, Abdul Majeed ,  SUN, Sean X. ,  INOUE, Takanari

IPC分类号： A61K31/335 ,  A61K31/7088 ,  A61K38/12 ,  A61K38/02 ,  A61K38/14

摘要： Described are conjugates of nucleic acid nanotubes and cells by linking the nanotubes to a cell surface moiety. Devices, kits, systems, and methods comprising the nanotube cell conjugates are also described.

公开(公告)号：WO2022076302A2

公开(公告)日：2022-04-14

申请号：PCT/US2021/053365

申请日：2021-10-04

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： SCHULMAN, Rebecca B. ,  SIEGAL, Daniel ,  LI, Yi ,  SCHAFFTER, Samuel ,  SCHNEIDER, Joanna

IPC分类号： C12Q1/6825 ,  G01N33/573 ,  G01N33/53 ,  C12N15/11 ,  B82Y15/00 ,  C12Q1/686

摘要： Described are systems comprising nucleic acid nanostructures, e.g., nanotubes, for use in detecting biological agents. The systems comprise a nucleic acid nanotube, nucleic acid nanotube seed, a plurality nucleic acid nanotube monomers, or a combination there of; a nucleic acid nanotube terminus; and an activation strand comprising a single-stranded nucleic acid comprising a first sequence complementary to a portion of the nucleic acid nanotube, nucleic acid nanotube seed, nucleic acid nanotube monomers and a second sequence complementary to a portion of the nucleic acid nanotube terminus. Devices, kits, and methods comprising the systems are also described.