公开(公告)号：WO2021053047A1

公开(公告)日：2021-03-25

申请号：PCT/EP2020/075927

申请日：2020-09-17

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  AUCKLAND UNISERVICES LIMITED

Inventor： JONES, David ,  ANDREWS, Gavin ,  SVIRSKIS, Darren ,  HILL, Andrew ,  BHUSAL, Prabhat ,  SHARMA, Manisha ,  AGARWAL, Priyanka ,  LI, Shu

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  A61K31/167 ,  A61K31/192 ,  A61K31/245 ,  A61K31/445 ,  A61P23/02 ,  A61P29/00

Abstract: The invention provides a device comprising: at least one biocompatible polymer; and an eutectic composition comprising a first agent and an agent capable of forming a eutectic composition with the first agent; or one or more fatty acids; or one or more fatty alcohols; or one or more fatty amines or combinations thereof. The device can be administered to a subject in need thereof an effective amount of one or more active agents. The at least one biocompatible polymer may be selected from the group comprising poly ethylene-vinyl-acetate, vinyl acetate, silicone, polycaprolactone, polylacticco-glycolic acid, polylactic acid or polyglycolic acid.

公开(公告)号：WO2020144377A1

公开(公告)日：2020-07-16

申请号：PCT/EP2020/050682

申请日：2020-01-13

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： TIAN, Yiwei ,  ANDREWS, Gavin ,  JONES, David

IPC: A61K9/51

Abstract: A water and solvent free Continuous Manufacturing platform for Nanoparticle Drug delivery systems (COMMAND), such as, self-dispersing solid lipid nanoparticles and proliposomal nanoparticles, and the nanoparticles made by such platform. Byremoving water and solvent from conventional processes, the formation of dry, solvent free self-dispersing solid lipid nanoparticles and dry, solvent free solid proliposomal nanoparticles can be performed using the COMMAND platform.