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    OCULAR COMPOSITIONS
    1.
    发明申请
    OCULAR COMPOSITIONS 审中-公开
    眼部组合物

    公开(公告)号：WO2017081154A1

    公开(公告)日：2017-05-18

    申请号：PCT/EP2016/077269

    申请日：2016-11-10

    Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

    Inventor： THAKUR, Raghu Raj Singh ,  JONES, David ,  GUJRAL, Chirag

    IPC: A61K47/08 ,  A61K47/14 ,  A61K47/34 ,  A61K31/573 ,  A61K31/58 ,  A61K38/38 ,  A61K39/395

    CPC classification number: A61K9/0051 ,  A61K31/573 ,  A61K31/58 ,  A61K38/00 ,  A61K47/08 ,  A61K47/14 ,  A61K47/34 ,  A61K2039/541 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76

    Abstract: The invention provides an ocular composition comprising: 99to 60 % (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.

    Abstract translation: 本发明提供一种眼用组合物，其包含：99-60％（w / w）的选自由聚亚烷基二醇二丙烯酸酯和聚亚烷基二醇二甲基丙烯酸酯组成的片段或单体的可光聚合组合物，其中所述可光聚合组合物 具有100至20,000道尔顿范围内的分子量; 选自脂族聚酯基聚氨酯，聚丙交酯，聚己内酯，聚原酸酯及其混合物，共聚物和嵌段共聚物的生物可降解聚合物; 光引发剂; 和治疗剂。 该组合物可用于形成眼部植入物和原位眼部植入物。

    COATING COMPOSITION AND USES THEREOF
    4.
    发明申请
    COATING COMPOSITION AND USES THEREOF 审中-公开
    涂料组合物及其用途

    公开(公告)号：WO2016142298A1

    公开(公告)日：2016-09-15

    申请号：PCT/EP2016/054679

    申请日：2016-03-04

    Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

    Inventor： MCCOY, Colin ,  GORMAN, Sean ,  JONES, David ,  CORBETT, Daniel ,  IRWIN, Nicola

    IPC: C09D4/06

    CPC classification number: C09D4/06 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  C08F271/02 ,  C08L39/06 ,  C08L51/00

    Abstract: The present invention provides a polymerizable coating composition comprising: (i) 1-vinyl-2-pyrrolidinone (NVP)and 2-hydroxyethyl methacrylate (2-HEMA) for forming a copolymer; (ii) a poly(vinyl pyrrolidone) (PVP) polymer having a molecular weight of at least 500,000 g.mol −1 ; (iii) a co-polymerizable crosslinker for crosslinking the 1-vinyl-2-pyrrolidinone (NVP)and the 2- hydroxyethyl methacrylate (2-HEMA); (iv) a co-polymerizable initiator for initiating co-polymerisation of the 1-vinyl-2-pyrrolidinone (NVP) and 2-hydroxyethyl methacrylate (2-HEMA); (v) a surfactant selected from non-ionic triblock copolymers of ethylene oxide/propylene oxide, nonionic triblock copolymers of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEO), tetrablock copolymers of PPO and PEO; Triton X-100 and derivatives thereof, polyethylene glycols and derivatives thereof, PEO derivatives of sorbitan monolaurate, and combinations of any two or more thereof; (vi) a solvent, wherein a vinyl component is 1-vinyl-2-pyrrolidinone for forming the copolymer and the PVP polymer, and an acrylate component is 2-hydroxyethyl methacrylate for forming the copolymer; wherein the vinyl and acrylate components are present at a molar ratio of between 10:1 and 1:10; and wherein 20-80% (w/w) of the vinyl componentis PVP polymer.

    Abstract translation: 本发明提供一种可聚合涂层组合物，其包含：（i）形成共聚物的1-乙烯基-2-吡咯烷酮（NVP）和甲基丙烯酸2-羟乙酯（2-HEMA） （ii）分子量至少为500,000g.mol-1的聚（乙烯基吡咯烷酮）（PVP）聚合物; （iii）用于交联1-乙烯基-2-吡咯烷酮（NVP）和甲基丙烯酸2-羟乙酯（2-HEMA）的共聚合交联剂; （iv）用于引发1-乙烯基-2-吡咯烷酮（NVP）和甲基丙烯酸2-羟乙酯（2-HEMA）的共聚合的共聚合引发剂; （v）选自环氧乙烷/环氧丙烷的非离子三嵌段共聚物，聚（环氧丙烷）（PPO）和聚（环氧乙烷）（PEO）的非离子三嵌段共聚物，PPO和PEO的四嵌段共聚物的表面活性剂; Triton X-100及其衍生物，聚乙二醇及其衍生物，山梨糖醇酐单月桂酸酯的PEO衍生物及其任意两种或多种的组合; （vi）溶剂，其中乙烯基组分是形成共聚物的1-乙烯基-2-吡咯烷酮和PVP聚合物，丙烯酸酯组分是用于形成共聚物的甲基丙烯酸2-羟乙酯; 其中乙烯基和丙烯酸酯组分以10:1至1:10的摩尔比存在; 并且其中20-80％（w / w）的乙烯基组分是PVP聚合物。

    OCULAR COMPOSITIONS
    5.
    发明申请
    OCULAR COMPOSITIONS 审中-公开

    公开(公告)号：WO2018206749A1

    公开(公告)日：2018-11-15

    申请号：PCT/EP2018/062181

    申请日：2018-05-10

    Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

    Inventor： THAKUR, Raghu Raj Singh ,  JONES, David ,  SONAWANE, Rahul

    IPC: A61K9/00 ,  A61K9/50 ,  A61K9/51

    Abstract: The invention provides methods of making microparticle and nanoparticle ocular implants from a composition comprising: 99 to 60 % (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.

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