-
公开(公告)号：WO2018093794A2
公开(公告)日：2018-05-24
申请号：PCT/US2017/061611
申请日：2017-11-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： VAN DAM, R. Michael , HA, Noel Seunghyun , JONES, Jason , LY, Jimmy , LIU, Stephen , CHEUNG, Shilin
Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
-
公开(公告)号：WO2018093794A3
公开(公告)日：2018-05-24
申请号：PCT/US2017/061611
申请日：2017-11-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： VAN DAM, R. Michael , HA, Noel Seunghyun , JONES, Jason , LY, Jimmy , LIU, Stephen , CHEUNG, Shilin
Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
-
公开(公告)号：WO2018067976A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055607
申请日：2017-10-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： HA, Noel Seunghyun , VAN DAM, R. Michael , LY, Jimmy
IPC: B01L3/00 , G01N27/447 , G01N27/453
Abstract: A volumetric microfluidic injector for capillary electrophoresis(CE) for highly repeatable sample injection has been designed and built to eliminate known injection bias in hydrodynamic injection. A defined volume from 1-10 nL or 0.1-100 nL of sample is confined in a defined region of a micro-valve PDMS microfluidic injector chip and electrophoretic potential is applied to drive sample into a separation device such as an embedded fused silica capillary for separation and detection. Using a 75 μm ID capillary, the RSD of an absorbance peak area as low as 1.32% (n=11) is obtained. As a comparison, the time-dependent injection was tested using the same chip which resulted in an inferior repeatability.
Abstract translation: 用于高度重复性样品注入的毛细管电泳（CE）的体积微流体注射器已被设计和构建，以消除流体动力学注射中已知的注射偏差。 将1-10nL或0.1-100nL样品的限定体积限定在微阀PDMS微流体注射器芯片的限定区域中，并且施加电泳电势以将样品驱入分离装置，例如嵌入的熔融石英毛细管用于 分离和检测。 使用75μmID毛细管，获得吸光度峰面积低至1.32％（n = 11）的RSD。 作为比较，使用相同的芯片对时间依赖性注射进行了测试，结果导致重复性较差。
-
-
Search Results
3
records
(took 0.011 seconds)
