公开(公告)号：WO2019036336A1

公开(公告)日：2019-02-21

申请号：PCT/US2018/046442

申请日：2018-08-13

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： NAGARAJ, Ram ,  LINETSKY, Mikhail ,  RAKETE, Stefan ,  NAHOMI, Rooban

IPC: A61K31/7088 ,  A61K38/54 ,  A61K45/06

Abstract: Compositions for the treatment and prevention of symptoms and disease conditions associated with oxidative and carbonyl stress, including advanced glycation end products (AGEs), and to methods using the compositions. In particular, the invention relates to compositions useful in the treatment of diabetic retinopathy and nephropathy, to compositions useful in the treatment of other retinal disorders including macular degeneration and cataracts.