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1.发明申请MONOCLONAL ANTIBODIES IMMUNOREACTIVE WITH LIPOPOLYSACCHARIDE BINDING PROTEIN (LBP) AND METHODS OF THEIR USE 审中-公开单克隆抗体与脂多糖结合蛋白（LBP）的免疫反应及其使用方法
公开(公告)号：WO1995014039A1
公开(公告)日：1995-05-26
申请号：PCT/US1994013199
申请日：1994-11-15
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： THE SCRIPPS RESEARCH INSTITUTE , KIRKLAND, Theo , TOBIAS, Peter , ULEVITCH, Richard , MORIARTY, Ann , LETURCQ, Didier
IPC: C07K16/18
CPC classification number: A61K49/0058 , A61K38/00 , A61K49/0043 , A61K51/1018 , C07K16/18 , Y10S436/804
Abstract: The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP antibody molecules in a pharmaceutically acceptable excipient is also contemplated.
Abstract translation: 本发明涉及治疗LBP介导的LPS诱导的骨髓细胞活化的方法，包括给予治疗有效量的抗LBP单克隆抗体分子。 还考虑了在药学上可接受的赋形剂中包含抗LBP抗体分子的治疗组合物。
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