公开(公告)号：WO2022155674A1

公开(公告)日：2022-07-21

申请号：PCT/US2022/070198

申请日：2022-01-14

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： BOLLONG, Michael ,  SCHULTZ, Peter ,  SHAO, Sida ,  CHATTERJEE, Arnab ,  CHEN, Jian ,  ZHANG, Nan

IPC: A61K31/403 ,  A61K31/4985 ,  A61K31/522 ,  A61K31/69 ,  A61P1/00 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/00 ,  A61P17/00 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/00

Abstract: The present disclosure relates to compounds, and to their pharmaceutical compositions, that inhibit dipeptidyl peptidase IV (DPP4). Hie compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology, for example, derives from epithelial degeneration and maladaptive remodeling, such as pulmonary' diseases like idiopathic pulmonary fibrosis (IFF), acute respiratory' distress syndrome (ARDS), and infant respiratory' distress syndromes (IRDS).

公开(公告)号：WO2022159955A1

公开(公告)日：2022-07-28

申请号：PCT/US2022/070259

申请日：2022-01-20

Applicant: THE SCRIPPS RESEARCH INSTITUTE ,  BOLLONG, Michael ,  SCHULTZ, Peter ,  SHAO, Sida ,  CHATTERJEE, Arnab ,  CHEN, Jian ,  ZHANG, Nan

Inventor： BOLLONG, Michael ,  SCHULTZ, Peter ,  SHAO, Sida ,  CHATTERJEE, Arnab ,  CHEN, Jian ,  ZHANG, Nan

IPC: C07D207/16 ,  C07D487/04 ,  A61P11/00 ,  A61K31/401

Abstract: The present disclosure relates to compounds, and to their pharmaceutical compositions, that inhibit dipeptidyl peptidase IV (DPP4). The compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology, for example, derives from epithelial degeneration and maladaptive remodeling, such as pulmonary diseases like idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), and infant respiratory distress syndromes (IRDS).