公开(公告)号：WO2020206348A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/026715

申请日：2020-04-03

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： CANNON, Carolyn, L. ,  SHAH, Kush ,  CHIRRA, Bhagath ,  CHEN, Qingquan ,  KHAN, Mansoor ,  WU, Hung-Jen

IPC: A61D1/02 ,  A61D7/00 ,  A61K9/00

Abstract: In an embodiment, a drug delivery system and method of use thereof to treat inflammation and bacterial pathogens including multi-drug resistant pathogens, such as MDR-Pseudomonas aeruginosa, or reactive oxygen species in a subject is provided. In some embodiments, the dmg delivery system includes a polymeric material, an excepient, an antioxidant agent, and an anti-inflammatory and antimicrobial agent. In some embodiments, the anti-inflammatory and antimicrobial agent is a salt of an anti-inflammatory agent and an antimicrobial agent formulated to provide a combination of antimicrobial and anti-inflammatory action from a single molecule. In some embodiments, the combined anti-inflammatory and antimicrobial agent is a silver salt of ibuprofen. In other embodiments, the combined anti-inflammatory and antimicrobial agent is unmodified, native ibuprofen.