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1.发明申请CROSS-CIRCULATION PLATFORM FOR RECOVERY, REGENERATION, AND MAINTENANCE OF EXTRACORPOREAL ORGANS 审中-公开用于恢复，再生和维持体外器官的循环平台
公开(公告)号：WO2018013849A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/041990
申请日：2017-07-13
Inventor： BACCHETTA, Matthew , CHICOTKA, Scott , FUNG, Kenmond , GUENTHART, Brandon , O'NEILL, John , VUNJAK-NOVAKOVIC, Gordana
Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.
Abstract translation: 描述了与器官，组织或生物工程移植物的常温体外支持有关的系统，方法和装置，其包括经由XC灌注延长的周期（数天至数周）的交叉循环（XC）灌注 公开了与体外宿主（例如，动物，患者，器官移植接受者）有关的电路。 XC灌注回路包括基于动脉压和静脉压之间的跨器官血压差自动调节血流量。 接受者支持使36h的常温灌注保持健康的肺，生理参数没有显着变化并且允许受伤的肺恢复。 扩展的支持使所有体外肺中的多尺度治疗干预成为可能。 肺超过移植标准。
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公开(公告)号：WO2018067938A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055549
申请日：2017-10-06
Inventor： BACCHETTA, Matthew , GUENTHART, Brandon , KIM, Jinho , O'NEILL, John , VUNJAK-NOVAKOVIC, Gordana
CPC classification number: A61L24/0031 , A61L24/0005 , A61L24/0036 , A61L24/0094 , A61L24/043 , A61L24/102 , A61L24/104 , A61L24/108
Abstract: Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.
Abstract translation: 公开了一种用于治疗肺部漏气的生物防腐剂体系和方法，包括将生物防腐剂体系应用于漏气部位。
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