专利检索 ap:("THE UNIVERSITY OF BRITISH COLUMBIA" OR "SIMON FRASER UNIVERSITY") AND inv:"LUO, Haiming" 第 1 页

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发明申请
CELL-SURFACE ENGINEERING COMPOSITIONS AND METHODS FOR THE PREVENTION OF IMMUNE REJECTION 审中-公开

公开(公告)号：WO2022266758A1

公开(公告)日：2022-12-29

申请号：PCT/CA2022/051000

申请日：2022-06-22

申请人： THE UNIVERSITY OF BRITISH COLUMBIA , SIMON FRASER UNIVERSITY

发明人： KIZHAKKEDATHU, Jayachandran , SIREN, Erika , CHOY, Jonathan , LUO, Haiming , WITHERS, Stephen , DU, Caigan , ENNS, Winnie

IPC分类号： C07K7/08 , A01N1/02 , C07H15/26 , C07K7/06 , C07K9/00 , C12N5/07

摘要： Provided herein are compounds including a linear polyglycerol, a peptide tag, with either a linker-sugar-sialic acid moiety or a sulfate group, a preservation solutions including the compounds, methods for using the compounds or the preservation solutions to cell surface engineering (CSE) of a cell, a tissue, an organ for transplant, and methods for making the compounds. In particular, the CSE may recapitulate or rebuild glycocalyx on the luminal endothelial surface of an organ to limit immune rejection of the organ after transplant.