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公开(公告)号：WO2003030908A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032195
申请日：2002-10-08
Applicant: THE UNIVERSITY OF CINCINNATI , FAGIN, James, Alexander
Inventor： FAGIN, James, Alexander
IPC: A61K31/505
CPC classification number: A61K31/00 , A61K31/505 , A61K31/517
Abstract: The present invention relates to a method of treating a warm-blooded animal, especially a human, having a disease which is mediated or characterized by mutations in the RET gene, or thyroid cancer, especially thyroid cancer harboring RET mutations, comprising administering to said animal a therapeutically effective amount of a compound which decreases the activity of the epidermal growth factor (EGF), especially a compound as defined herein.
Abstract translation: 本发明涉及一种治疗具有RET基因或甲状腺癌，特别是具有RET突变的甲状腺癌的突变介导或表征的疾病的温血动物，特别是人的方法，包括对所述动物施用 治疗有效量的降低表皮生长因子（EGF）的活性的化合物，特别是本文定义的化合物。
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公开(公告)号：WO2003030908A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032195
申请日：2002-10-08
Applicant: THE UNIVERSITY OF CINCINNATI , FAGIN, James, Alexander
Inventor： FAGIN, James, Alexander
IPC: A61K31/505
Abstract: The present invention relates to a method of treating a warm-blooded animal, especially a human, having a disease which is mediated or characterized by mutations in the RET gene, or thyroid cancer, especially thyroid cancer harboring RET mutations, comprising administering to said animal a therapeutically effective amount of a compound which decreases the activity of the epidermal growth factor (EGF), especially a compound as defined herein.
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3.发明申请4-4(METHYLPIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO)PHENYL]-BENZAMIDE FOR TREATING MUTATED-RET KINASE ASSOCIATED DISEASES 审中-公开4-4（甲基哌嗪-1-基甲基）-N- [4-甲基-3-（吡啶-3-基）嘧啶-2-基氨基）苯基] - 苯甲酰胺，用于治疗突变型激酶相关疾病
公开(公告)号：WO2004009087A1
公开(公告)日：2004-01-29
申请号：PCT/IB2003/001984
申请日：2003-05-23
Applicant: UNIVERSITY OF CINCINNATI , FAGIN, James, Alexander
Inventor： FAGIN, James, Alexander
IPC: A61K31/506
CPC classification number: A61K31/506
Abstract: The invention relates to the use of 4-(4-methylpiperazin-l-ylmethyl)-N-(4-methyl-3-(4-pyridin3-yl)pyrimidin-2-ylamino)phenyl]-benzamide or a pharmaceutically acceptable salt thereof for the treatment of mutated-RET kinase associated disease, especially mutated-RET kinase associated thyroid cancer.
Abstract translation: 本发明涉及4-（4-甲基哌嗪-1-基甲基）-N-（4-甲基-3-（4-吡啶-3-基）嘧啶-2-基氨基）苯基] - 苯甲酰胺或其药学上可接受的盐 用于治疗突变的RET激酶相关疾病，特别是突变的RET激酶相关甲状腺癌。
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