公开(公告)号：WO2017151582A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/019889

申请日：2017-02-28

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： ALLBRITTON, Nancy ,  WANG, Yuli ,  SIMS, Christopher ,  DOBES, Nicholas C. ,  GEBHART, Steven C. ,  TROTTA, Nicholas Clayton

IPC: C12M1/32 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

CPC classification number: C12M23/20 ,  C12M23/12 ,  C12M23/26 ,  C12M25/04 ,  C12M41/36

Abstract: An array of magnetic or paramagnetic micro-elements comprised of polysilsesquioxane is described having ultra-low-autofluorescence and other optical properties to improve microscopic imaging of cells or other objects present on the array. These materials are also amenable to chemical modification allowing surface attachment of affinity capture moieties or chemical reporters for selective binding or analysis of cells, macromolecules or other targets.

Abstract translation: 描述了由聚倍半硅氧烷组成的磁性或顺磁性微元件阵列，其具有超低自发荧光性和其他光学性质，以改善存在于阵列上的细胞或其它物体的显微成像。 这些材料也适用于化学修饰，允许表面附着亲和捕获部分或化学报道分子用于选择性结合或分析细胞，大分子或其他靶标。