公开(公告)号：WO2014048480A1

公开(公告)日：2014-04-03

申请号：PCT/EP2012/069141

申请日：2012-09-27

Applicant: THE UNIVERSITY OF SUSSEX

Inventor： HOFFMANN, Eva, Ran ,  VISEUX, Eddy, Michel, Elie ,  NEWCOMBE, Sonya, Clare

IPC: C07F9/50 ,  A61P35/00

CPC classification number: C07F9/5045 ,  C07C311/09 ,  C07C323/59 ,  C07F9/5022 ,  C07F9/5721 ,  C07F9/5722

Abstract: The present invention relates to gold complexes that find use in therapy, particularly in treating cancer. The compounds of the invention have formula (I) wherein L denotes a phosphine or N-heterocyclic carbene ligand; A denotes SO 2 or C(=O); R denotes hydrogen, alkyl, or haloalkyl; or optionally substituted (hetero)aryl; and G denotes hydrogen, alkyl, cycloalkyi, (hetero)aryl, A-R, or a group deriving from an a- or β-amino acid.

Abstract translation: 本发明涉及用于治疗，特别是治疗癌症的金络合物。 本发明化合物具有式（I），其中L表示膦或N-杂环卡宾配体; A表示SO2或C（= O）; R表示氢，烷基或卤代烷基; 或任选取代的（杂）芳基; 和G表示氢，烷基，环烷基，（杂）芳基，A-R或衍生自α-或β-氨基酸的基团。