公开(公告)号：WO2022165395A1

公开(公告)日：2022-08-04

申请号：PCT/US2022/014658

申请日：2022-02-01

Applicant: THE UNIVERSITY OF TOLEDO

Inventor： ERHARDT, Paul ,  LIU, Shi-He ,  BRUNICARDI, Francis, Charles ,  ANDY, Divya

IPC: A61K31/155 ,  C07C69/74 ,  C07C13/48 ,  C07C13/47 ,  A61P35/00 ,  C07C13/32

Abstract: Stably consolidated compounds assembled from a statin and a metformin analog, and metabolically labile dual prodrugs assembled from the same, methods of making both, and methods of using them to treat metabolic diseases such as cancers are described.

公开(公告)号：WO2019051207A1

公开(公告)日：2019-03-14

申请号：PCT/US2018/049927

申请日：2018-09-07

Applicant: THE UNIVERSITY OF TOLEDO

Inventor： HECK, Bruce, E. ,  KIM, Dong, Hyun ,  ERHARDT, Paul ,  KRESS, Brian

IPC: A61K31/426 ,  C07D277/22

Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.