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    HEAT TRANSFER FLUID BASED ON POLYPHENYLMETHANES EXHIBITING IMPROVED THERMAL STABILITY
    3.
    发明申请
    HEAT TRANSFER FLUID BASED ON POLYPHENYLMETHANES EXHIBITING IMPROVED THERMAL STABILITY 审中-公开
    基于聚苯乙烯的换热流体展现改进的热稳定性

    公开(公告)号：WO01072924A1

    公开(公告)日：2001-10-04

    申请号：PCT/FR2001/000930

    申请日：2001-03-27

    IPC: C07C2/86 ,  C07B61/00 ,  C07C7/04 ,  C07C13/47 ,  C09K5/08 ,  C09K5/10

    CPC classification number: C09K5/10

    Abstract: The invention concerns a heat transfer fluid comprising a monobenzyl-1,2,3,4-tetrahydronaphthalene or a mixture of mono-and polybenzyl-1,2,3,4-tetrahydronaphthalene and/or a mixture of partly hydrogenated polyphenyls and at least a polyphenylmethane composition.

    Abstract translation: 本发明涉及一种传热流体，其包含单苄基-1,2,3,4-四氢化萘或单苄基-1,2,3,4-四氢化萘和/或部分氢化的多苯基的混合物和至少 聚苯甲烷组合物。

    INTEGRIN TARGETING LIGANDS AND USES THEREOF
    4.
    发明申请
    INTEGRIN TARGETING LIGANDS AND USES THEREOF 审中-公开

    公开(公告)号：WO2022056286A1

    公开(公告)日：2022-03-17

    申请号：PCT/US2021/049905

    申请日：2021-09-10

    Applicant: ARROWHEAD PHARMACEUTICALS, INC.

    Inventor： LI, Xiaokai ,  PEI, Tao ,  PHAN, Susan ,  BLOKHIN, Andrei, V.

    IPC: C07C13/47 ,  C12N15/09 ,  C12N15/111

    Abstract: Synthetic ανβ6 integrin ligands of Formula (I) having serum stability and affinity for integrin ανβ6, which is a receptor expressed in a variety of cell types, are described. The described ligands are usful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin ανβ6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ανβ6 integrin ligands and methods of use are also described Formula (I).

    MEMORY MANIPULATION VIA MODIFICATION OF PROTEIN KINASE C ZETA ACTIVITY
    8.
    发明申请
    MEMORY MANIPULATION VIA MODIFICATION OF PROTEIN KINASE C ZETA ACTIVITY 审中-公开

    公开(公告)号：WO2019075453A9

    公开(公告)日：2019-04-18

    申请号：PCT/US2018/055830

    申请日：2018-10-15

    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK ,  ACEVEDO-DUNCAN, Mildred

    Inventor： ACEVEDO-DUNCAN, Mildred ,  SACKTOR, Todd

    IPC: A61K31/015 ,  A61K31/10 ,  C07C13/47

    Abstract: Provided is a method of inhibiting protein kinase C zeta/protein kinase M zeta, including contacting a sample containing an isoform of protein kinase C zeta with a compound of formula: referred to as 1-naphthol-3,6,8-trisulphonic acid, or a pharmaceutically acceptable salt thereof. In some embodiments, contacting the sample with the compound does not inhibit protein kinase C iota/lambda. In a specific example, the sample includes neural tissue, the isoform of protein kinase C zeta is protein kinase M zeta, and inhibiting includes reducing kinase activity and further includes diminishing long-term potentiation. In some embodiment, the method includes inhibiting glucose transport. Also provided is a method of affecting memory, including administering the compounds to a mammalian organism.

    シクロペンテンの製造方法
    10.
    发明申请
    シクロペンテンの製造方法 审中-公开

    公开(公告)号：WO2022210164A1

    公开(公告)日：2022-10-06

    申请号：PCT/JP2022/013507

    申请日：2022-03-23

    Applicant: 日本ゼオン株式会社

    Inventor： 三木　英了

    IPC: C07C5/05 ,  B01J23/44 ,  C07B61/00 ,  C07C4/22 ,  C07C13/12 ,  C07C13/47

    Abstract: 本発明は、生産安定性に優れ、且つ、高純度のシクロペンテンを高収率で製造可能なシクロペンテンの製造方法の提供を目的とする。本発明のシクロペンテンの製造方法は、水素化触媒とシクロペンテンの存在下、ゲージ圧が０ＭＰａ以上０．３ＭＰａ以下の条件下で、シクロペンタジエンの気相接触水素添加を行う水素添加工程を備え、前記水素化触媒は、活性炭に貴金属を担持してなる。

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