公开(公告)号：WO2022011325A8

公开(公告)日：2022-01-13

申请号：PCT/US2021/041199

申请日：2021-07-10

申请人： TING THERAPEUTICS LLC

发明人： ZUO, Jian ,  DERMANAKI, Pezhman, Salehi ,  ZALLOCCHI, Marisa, Laura ,  VIJAYAKUMAR, Sarath

IPC分类号： A61K31/167 ,  A61K31/4035 ,  A61K45/06 ,  A61K31/165 ,  A61K31/22 ,  A61K31/397 ,  A61K31/609 ,  A61K33/24

摘要： Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise- induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：WO2022011325A1

公开(公告)日：2022-01-13

申请号：PCT/US2021/041199

申请日：2021-07-10

申请人： TING THERAPEUTICS LLC

发明人： ZUO, Jian ,  DERMANAKI, Pezhman, Salehi ,  ZALLOCCHI, Zarisa, Laura ,  VIJAYKUMAR, Sarath

IPC分类号： A61K31/167 ,  A61K31/4035 ,  A61K45/06

摘要： Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise- induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.