公开(公告)号：WO2021198415A1

公开(公告)日：2021-10-07

申请号：PCT/EP2021/058604

申请日：2021-04-01

Applicant: SOFTHALE NV

Inventor： RAWERT, Jürgen ,  TEWS, Jan-Torsten

IPC: A61K9/08 ,  A61K9/12 ,  A61M11/00 ,  A61K31/609 ,  A61P11/00 ,  A61P31/14 ,  A61K31/045 ,  A61K31/167 ,  A61K9/0078 ,  A61M15/0008 ,  A61M15/0021 ,  A61M15/0063

Abstract: The present invention provides for a method for the treatment of a respiratory disease, disorder or condition, or a viral infection or viral disease, disorder or condition in a subject, the method comprising the step of administering to said subject a medically active liquid in nebulized form by inhalation, wherein the medically active liquid comprises niclosamide or a pharmaceutically acceptable salt thereof and wherein the medically active liquid is administered in nebulized form using an inhalation device.

公开(公告)号：WO2021168328A1

公开(公告)日：2021-08-26

申请号：PCT/US2021/018880

申请日：2021-02-19

Applicant: YOURCHOICE THERAPEUTICS, INC.

Inventor： MANNOWETZ, Nadja ,  BAKSHI, Akash ,  BARTYNSKI, Andrew

IPC: A61K31/609 ,  A61K9/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/38 ,  A61K47/36 ,  A61K47/34 ,  A61K47/32 ,  A61P15/18 ,  A61P15/16 ,  A61K9/00

Abstract: A formulation comprising an amount of niclosamide and one or more of a humectant, a lubricant, a solvent, an osmolality modulator, a pH modulator, a viscosity modulator, a preservative, or combinations thereof. Said formulation for use in promoting contraception, comprising administering an effective amount of the formulation to the subject, wherein, upon contacting a sperm cell, the formulation inhibits or decreases one or more of sperm motility, sperm viability, and sperm metabolism, thereby decreasing the probability of conception. A method of making said formulation, comprising: a) combining niclosamide with PEG-400 in a first vessel to form a solution; b) combining benzoic acid and/or benzyl alcohol with the solution of (a); c) combining water, sodium chloride, citric acid, lactic acid, potassium tartrate and carbopol 980 in a separate vessel to form an aqeous fraction; d) combining the aqueous fraction of (c) with the PEG fraction of (b); e) adding sodium hydroxide to the mixture of (d) to adjust the pH; f) optionally adding water to the mixture of (e); and g) mixing the mixture of (e) or (f) till a homogenous mixture is obtained.

公开(公告)号：WO2021122239A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/085338

申请日：2020-12-09

Applicant: UNIVERSITÄT REGENSBURG ,  FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG

Inventor： KUNZELMANN, Karl ,  SCHREIBER, Rainer ,  BUCHHOLZ, Björn

IPC: A61K31/343 ,  A61K31/436 ,  A61K31/609 ,  A61K31/55 ,  A61K38/12 ,  A61K45/06 ,  A61P1/16 ,  A61P13/12

Abstract: The present invention relates to a compound for use in a method of treating a pathological condition selected from polycystic kidney disease, polycystic liver disease, and a combination thereof. The present invention further relates to a composition for use in a method of treating a pathological condition selected from polycystic kidney disease, polycystic liver disease, and a combination thereof.

公开(公告)号：WO2019053180A1

公开(公告)日：2019-03-21

申请号：PCT/EP2018/074863

申请日：2018-09-14

Applicant: CEVA SANTE ANIMALE

Inventor： GUYONNET, Jérôme ,  ZEMIRILINE, Claudine ,  BUTTY, Pascal

IPC: A61K9/00 ,  A61K47/10 ,  A61K47/20 ,  A61K31/609

Abstract: The present invention relates to a new topical composition comprising niclosamide and/or oxyclozanide and to the use of said composition for the treatment or prevention of pyoderma or dermatitis in non-human mammals.

公开(公告)号：WO2019038443A1

公开(公告)日：2019-02-28

申请号：PCT/EP2018/072933

申请日：2018-08-24

Applicant: ANTIBIOTX A/S

Inventor： SOMMER, Morten, Otto, Alexander, ,  TOFT-KEHLER, Rasmus, Vendler,

IPC: A61K31/609 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06 ,  A61K9/107 ,  A61P31/04 ,  A61P17/00

CPC classification number: A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K31/609 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61P17/00 ,  A61P31/04

Abstract: A dosage regimen for the topical prevention or treatment of a skin infection or an inflammatory skin condition in a human subject using a halogenated salicylanilide. The topical dosage regimen provides high concentrations of the halogenated salicylanilide in skin tissue which are retained for a prolonged period without the need for further topical dosing of the halogenated salicylanilide.

公开(公告)号：WO2018210449A1

公开(公告)日：2018-11-22

申请号：PCT/EP2018/000267

申请日：2018-05-18

Applicant: VETERINÄRMEDIZINISCHE UNIVERSITÄT WIEN

Inventor： ERBEN, Reinhold, G.

IPC: A61K31/429 ,  A61K31/435 ,  A61K31/4545 ,  A61K31/609 ,  A61P13/12

CPC classification number: A61K31/609 ,  A61K31/429 ,  A61K31/435 ,  A61K31/4545 ,  A61P13/12

Abstract: The invention discloses WNK signalling inhibitors, in particular closantel, for use in the prevention and treatment of disorders caused and/or characterized by elevated levels of serum fibroblast growth factor (FGF23), especially chronic kidney disease (CKD). The invention also provides pharmaceutical compositions comprising one/or more WNK signalling inhibitors and methods for use said pharmaceutical compositions in the treatment of subjects diagnosed with FGF23-associated disorders, wherein subjects may be humans and/or companion animals, e.g. dogs and cats.

公开(公告)号：WO2017127397A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/013873

申请日：2017-01-18

Applicant: THE UNITED STATES OF AMERICA, AS REPESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： KEBEBEW, Electron ,  ZHANG, Lisa ,  ZHANG, Ya-qin ,  SHEN, Min

IPC: A61K31/03 ,  A61K31/282 ,  A61K31/305 ,  A61K31/315 ,  A61K31/438 ,  A61K31/4745 ,  A61K31/4995 ,  A61K31/538 ,  A61K31/55 ,  A61K31/609 ,  A61K31/65 ,  A61K31/7008 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7135 ,  A61P35/00

CPC classification number: A61K31/609 ,  A61K31/03 ,  A61K31/282 ,  A61K31/305 ,  A61K31/315 ,  A61K31/438 ,  A61K31/4745 ,  A61K31/4995 ,  A61K31/538 ,  A61K31/55 ,  A61K31/65 ,  A61K31/7008 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7135 ,  A61K2300/00

Abstract: Disclosed herein are methods of treating a malignant adrenocortical tumor, including a locally advanced and metastatic adrenocortical carcinoma. In some examples, methods of treating a malignant adrenocortical tumor include administering an effective amount of niclosamide alone or in combination with other therapeutic agents to a subject in need thereof, thereby treating the malignant adrenocortical tumor.

Abstract translation: 本文公开了治疗恶性肾上腺皮质肿瘤（包括局部晚期和转移性肾上腺皮质癌）的方法。 在一些实例中，治疗恶性肾上腺皮质肿瘤的方法包括单独或与其它治疗剂组合给予有效量的氯硝柳胺给有需要的受试者，从而治疗恶性肾上腺皮质肿瘤。

公开(公告)号：WO2016120729A1

公开(公告)日：2016-08-04

申请号：PCT/IB2016/000275

申请日：2016-01-27

Applicant: ASTRAZENECA AB ,  STOREY, Robert ,  THE UNIVERSITY OF SHEFFIELD ,  SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST

Inventor： STOREY, Robert

IPC: A61K31/519 ,  A61K31/60 ,  A61K31/609 ,  A61P9/00 ,  A61P9/10

CPC classification number: A61K31/519 ,  A61K9/20 ,  A61K31/60 ,  A61K31/609 ,  A61K31/616 ,  A61K2300/00

Abstract: The present disclosure relates to methods for reducing the rate of cardiovascular death, myocardial infarction, or stroke in a patient in recognized need thereof, comprising administering to the patient a pharmaceutical composition comprising 60 mg ticagrelor twice daily.

Abstract translation: 本公开涉及在公认的需要中降低患者心血管死亡，心肌梗死或中风的发生率的方法，包括向患者施用包含60mg替卡格雷每天两次的药物组合物。

公开(公告)号：WO2011137601A1

公开(公告)日：2011-11-10

申请号：PCT/CN2010/074130

申请日：2010-06-21

Applicant: 施慧达药业集团(吉林)有限公司 ,  杨彦玲 ,  薛传校 ,  张喜田 ,  李环 ,  宋森涛

Inventor： 杨彦玲 ,  薛传校 ,  张喜田 ,  李环 ,  宋森涛

IPC: A61K31/4422 ,  A61K31/403 ,  A61K31/609 ,  A61K31/427 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K9/14 ,  A61P9/12

CPC classification number: A61K31/403 ,  A61K9/2054 ,  A61K31/166 ,  A61K31/427 ,  A61K31/4422

Abstract: 本发明公开了一种左旋氨氯地平复方药物组合物，其包括左旋氨氯地平或其药学上可接受的盐，以及β兼α受体阻滞剂。本发明将左旋氨氯地平与β兼α受体阻滞剂联合用药用于治疗高血压，相互之间具有良好的协同降压作用，在达到相同甚至更优的降血压效果的同时，可以降低左旋氨氯地平与β兼α受体阻滞剂的给药剂量，减少了单药大剂量引起的不良反应。另外β兼α受体阻滞剂还可抑制左旋氨氯地平所引起的反射性心动过速。

公开(公告)号：WO2011098839A3

公开(公告)日：2011-08-18

申请号：PCT/GB2011/050284

申请日：2011-02-15

Applicant: THE UNIVERSITY OF WOLVERHAMPTON ,  PERRY, Christopher, John ,  NICHOLL, Iain, Douglas

Inventor： PERRY, Christopher, John ,  NICHOLL, Iain, Douglas

IPC: A61K31/60 ,  A61K31/609 ,  A61K31/616 ,  A61K31/621 ,  C07C69/86 ,  C07C69/96 ,  C07C203/04 ,  C07C205/43 ,  C07C235/60 ,  A61P35/00

Abstract: The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.