公开(公告)号：WO2022051029A2

公开(公告)日：2022-03-10

申请号：PCT/US2021/041197

申请日：2021-07-10

申请人： TING THERAPEUTICS LLC

发明人： ZUO, Jian ,  LI, Zhuo ,  FLEEGEL, Jonathan ,  ZALLOCCHI, Marisa, Laura

IPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/165 ,  A61K31/22 ,  A61K31/397 ,  A61K31/609 ,  A61K33/24

摘要： In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.