公开(公告)号：WO2022229350A2

公开(公告)日：2022-11-03

申请号：PCT/EP2022/061404

申请日：2022-04-28

申请人： TIRMED PHARMA AB

发明人： SPETZ, Anna-Lena

IPC分类号： C12N15/11 ,  A61K31/7125 ,  A61K45/06 ,  A61P31/14 ,  A61P31/18 ,  A61P31/22 ,  C12N15/1131 ,  C12N2310/18 ,  C12N2310/315

摘要： The present disclosure relates to non-CpG single-stranded oligonucleotides (ssONs) with broad-spectrum antiviral activity for use in the treatment and/or prophylaxis of viral infections, such as Herpes simplex virus, Ebola virus, Lassa virus, Lyssa virus, rabies virus, measles virus, vesicular stomatitis virus (VSV), murine leukemia virus (MLV) and HIV-1, as well as multi-resistant HIV-1 infections, in a subject. Said ssONs have a length of at least 25 nucleotides and are stabilized by phosphorothioate internucleotide linkages and/or 2'-O-Methyl modifications.