公开(公告)号：WO2004028457A2

公开(公告)日：2004-04-08

申请号：PCT/US2003/030287

申请日：2003-09-26

Applicant: TRIMERIS, INC.

Inventor： DI, Jie ,  HEILMAN, David ,  BRAY, Brian

IPC: A61K

CPC classification number: A61K9/0019 ,  A61K38/162 ,  A61K47/10 ,  A61K47/26

Abstract: Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Also provided is a synthetic peptide-containing pharmaceutical composition as a unit dose comprising an aqueous formulation comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Further provided is a method of treating HIV infection by administering to an HIV-infected individual a pharmaceutical composition according to the present invention.

Abstract translation: 本发明提供一种药物组合物，其包含与多元醇混合的终浓度不小于70mg / ml的合成肽的溶液; 其中所述合成肽是HIV融合抑制剂，并且其中所述多元醇的终浓度不低于所述药物组合物的5重量％且不大于75重量％。 还提供了含合成肽的药物组合物作为单位剂量，其包含由多元醇混合而成的最终浓度不小于70mg / ml的合成肽的水性制剂; 其中所述合成肽是HIV融合抑制剂，并且其中所述多元醇的终浓度不低于所述药物组合物的5重量％且不大于75重量％。 还提供了通过向HIV感染个体施用根据本发明的药物组合物来治疗HIV感染的方法。

公开(公告)号：WO2006105201A3

公开(公告)日：2006-10-05

申请号：PCT/US2006/011474

申请日：2006-03-28

Applicant: TRIMERIS, INC. ,  WRING, Stephen ,  FRICK, Lloyd ,  SCHNEIDER, Stephen ,  ZHANG, Huyi ,  DI, Jie ,  HEILMAN, David

Inventor： WRING, Stephen ,  FRICK, Lloyd ,  SCHNEIDER, Stephen ,  ZHANG, Huyi ,  DI, Jie ,  HEILMAN, David

IPC: C07K5/00

Abstract: Provided is a conjugate comprised of HIV gp41 -derived peptide operatively linked to fatty acid, and pharmaceutical compositions and medicaments containing the conjugate. Also provided are methods for producing a conjugate according to the present invention which include, but are not limited to, covalently coupling a linker to the HIV gp41 -derived peptide, wherein the linker is covalently coupled to fatty acid.

公开(公告)号：WO2010047826A2

公开(公告)日：2010-04-29

申请号：PCT/US2009/005781

申请日：2009-10-23

Applicant: TRIMERIS, INC. ,  BRAY, Brian, L. ,  DI, Jie ,  GREENBERG, Michael ,  HEILMAN, David ,  OHMSTEDE, Carol ,  SILINSKI, Peter ,  WEBB, Scott

Inventor： BRAY, Brian, L. ,  DI, Jie ,  GREENBERG, Michael ,  HEILMAN, David ,  OHMSTEDE, Carol ,  SILINSKI, Peter ,  WEBB, Scott

IPC: A61K9/00

CPC classification number: A61K38/162

Abstract: Provided herein are dosage formulations and dosing regimens of an antiviral peptide therapeutic, including methods of using the same.

Abstract translation: 本文提供了抗病毒肽治疗剂的剂型和给药方案，包括使用它们的方法。

公开(公告)号：WO2008124013A1

公开(公告)日：2008-10-16

申请号：PCT/US2008/004307

申请日：2008-04-02

Applicant: TRIMERIS, INC. ,  BRAY, Brian, L. ,  DI, Jie ,  HEILMAN, David ,  SILINSKI, Peter ,  WEBB, Scott

Inventor： BRAY, Brian, L. ,  DI, Jie ,  HEILMAN, David ,  SILINSKI, Peter ,  WEBB, Scott

IPC: A61K47/48

CPC classification number: A61K38/162 ,  A61K9/0024 ,  A61K38/19 ,  A61K47/26 ,  A61K47/34 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for their administration as therapeutic agents. In particular, provided herein are compositions and their use for the administration of antiviral peptide therapeutics.

Abstract translation: 本文提供了作为治疗剂施用的组合物和方法。 特别地，本文提供了组合物及其用于施用抗病毒肽治疗剂的用途。